Rudolph, Volker, Augustin, Jahan, Hofmann, Thomas, Hamm, Christian W. ORCID: 0000-0001-6763-4161, Meinertz, Thomas, Koester, Ralf, Baldus, Stephan and Franzen, Olaf (2014). Predictors of recurrent stroke after percutaneous closure of patent foramen ovale. EuroIntervention, 9 (12). S. 1418 - 1423. TOULOUSE CEDEX 6: EUROPA EDITION. ISSN 1969-6213

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Abstract

Aims: Closure of patent foramen ovale following presumed paradoxical embolic stroke remains controversial. The answer to the question as to whether cardiovascular risk factors (CVRF) impact on the recurrence of stroke in patients who have undergone PFO closure remains elusive so far. We aimed to investigate the potential impact of CVRF on the long-term rate of stroke/TIA recurrence in patients treated with an occluder following presumed paradoxical embolic stroke. Methods and results: 443 patients (mean age: 50.0 +/- 12.6 yrs, female: 206 [46.5%]) undergoing percutaneous PFO closure after presumed paradoxical embolic stroke were followed for a median time of 43.0 [inter-quartile range: 20.0-86.0] months. During the follow-up period a total of 22 (5.0%) strokes/TIAs and 17 (3.8%) deaths were observed. Cox regression analysis identified hypertension, age and the Essen stroke risk score as predictors of recurrent stroke/TIA. Conclusions: This study shows that, in patients with a prior presumed paradoxical embolic stroke, the risk for recurrent stroke/TIA after PFO closure is firmly linked to the presence of CVRF.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rudolph, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Augustin, JahanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofmann, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamm, Christian W.UNSPECIFIEDorcid.org/0000-0001-6763-4161UNSPECIFIED
Meinertz, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koester, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baldus, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franzen, OlafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-441027
DOI: 10.4244/EIJV9I12A239
Journal or Publication Title: EuroIntervention
Volume: 9
Number: 12
Page Range: S. 1418 - 1423
Date: 2014
Publisher: EUROPA EDITION
Place of Publication: TOULOUSE CEDEX 6
ISSN: 1969-6213
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CRYPTOGENIC STROKE; MEDICAL-TREATMENT; THERAPYMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/44102

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