Universität zu Köln

Zuccaro, Emanuela, Bergami, Matteo ORCID: 0000-0001-5525-5025, Vignoli, Beatrice ORCID: 0000-0001-9689-6224, Bony, Guillaume, Pierchala, Brian A., Santi, Spartaco ORCID: 0000-0001-9856-7053, Cancedda, Laura ORCID: 0000-0003-0566-057X and Canossa, Marco ORCID: 0000-0003-3898-2030 (2014). Polarized Expression of p75(NTR) Specifies Axons during Development and Adult Neurogenesis. Cell Reports, 7 (1). S. 138 - 153. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

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Abstract

Newly generated neurons initiate polarizing signals that specify a single axon and multiple dendrites, a process critical for patterning neuronal circuits in vivo. Here, we report that the pan-neurotrophin receptor p75(NTR) is a polarity regulator that localizes asymmetrically in differentiating neurons in response to neurotrophins and is required for specification of the future axon. In cultured hippocampal neurons, local exposure to neurotrophins causes early accumulation of p75(NTR) into one undifferentiated neurite to specify axon fate. Moreover, knockout or knockdown of p75(NTR) results in failure to initiate an axon in newborn neurons upon cell-cycle exit in vitro and in the developing cortex, as well as during adult hippocampal neurogenesis in vivo. Hence, p75(NTR) governs neuronal polarity, determining pattern and assembly of neuronal circuits in adult hippocampus and cortical development.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zuccaro, Emanuela UNSPECIFIED UNSPECIFIED UNSPECIFIED Bergami, Matteo UNSPECIFIED orcid.org/0000-0001-5525-5025 UNSPECIFIED Vignoli, Beatrice UNSPECIFIED orcid.org/0000-0001-9689-6224 UNSPECIFIED Bony, Guillaume UNSPECIFIED UNSPECIFIED UNSPECIFIED Pierchala, Brian A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Santi, Spartaco UNSPECIFIED orcid.org/0000-0001-9856-7053 UNSPECIFIED Cancedda, Laura UNSPECIFIED orcid.org/0000-0003-0566-057X UNSPECIFIED Canossa, Marco UNSPECIFIED orcid.org/0000-0003-3898-2030 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-442041
DOI:	10.1016/j.celrep.2014.02.039
Journal or Publication Title:	Cell Reports
Volume:	7
Number:	1
Page Range:	S. 138 - 153
Date:	2014
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	2211-1247
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEURONAL POLARIZATION; HIPPOCAMPAL-NEURONS; NEUROTROPHIN RECEPTORS; NOGO RECEPTOR; GROWTH; SECRETION; BDNF; INTEGRATION; DENDRITES; DELETION Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44204