Universität zu Köln

Bosse, Kristin, Graeser, Monika, Gossmann, Axel, Hackenbroch, Matthias, Schmutzler, Rita K. and Rhiem, Kerstin (2014). Supplemental screening ultrasound increases cancer detection yield in BRCA1 and BRCA2 mutation carriers. Arch. Gynecol. Obstet., 289 (3). S. 663 - 671. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-0711

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Abstract

This study aimed at evaluating the efficacy of ultrasound for the early detection of breast cancers in BRCA1/2 mutation carriers. Between 01/1997 and 10/2008 221 BRCA1/2 mutation carriers participated in a breast cancer screening program which included semi-annual ultrasound in combination with annual mammography and magnetic resonance imaging (MRI). Women underwent on average (median) five semi-annual screening rounds with a range of one to 22 appointments, totaling 1,855 rounds of screening. All three imaging modalities were coded according to the American College of Radiology (BI-RADS classification). In total, we detected 27 BRCA-associated breast cancers in 25 patients. The sensitivity was 77 % for ultrasound, 27 % for mammography, and 100 % for MRI. Three tumors were detected directly as a result of only the semi-annual ultrasound screen. Due to the specific tumor morphology and the considerably elevated tumor doubling time, mutation carriers benefit from the addition of semi-annual ultrasound screening as a sensitive and cost-effective method.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bosse, Kristin UNSPECIFIED UNSPECIFIED UNSPECIFIED Graeser, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Gossmann, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Hackenbroch, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, Rita K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-445101
DOI:	10.1007/s00404-013-3022-6
Journal or Publication Title:	Arch. Gynecol. Obstet.
Volume:	289
Number:	3
Page Range:	S. 663 - 671
Date:	2014
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-0711
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BREAST-CANCER; OVARIAN-CANCER; WOMEN; MRI; MAMMOGRAPHY; RISK; GENE; SURVEILLANCE; HISTORY; GROWTH Multiple languages Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44510