Universität zu Köln

Streckmann, F., Kneis, S., Leifert, J. A., Baumann, F. T., Kleber, M., Ihorst, G., Herich, L., Gruessinger, V., Gollhofer, A. and Bertz, H. (2014). Exercise program improves therapy-related side-effects and quality of life in lymphoma patients undergoing therapy. Ann. Oncol., 25 (2). S. 493 - 500. OXFORD: OXFORD UNIV PRESS. ISSN 1569-8041

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Abstract

Background: Exercise is beneficial and clinically meaningful for lymphoma patients undergoing therapy. It reduces side-effects of therapy such as balance control and peripheral neuropathy, subsequently improving patients' quality of life. Together with physical functioning, they are decisive factors for patients to receive their planned therapy regime, optimizing cancer control.Lymphoma patients undergoing therapy must cope with the side-effects of the disease itself, therapy and associated immobility. Peripheral neuropathy (PNP), loss of balance control and weakness not only diminishes patients' quality of life (QOL), it can also affect planning and the dosage of therapy. Exercise may enable patients to reverse these declines, improving their performance level and QOL. We carried out a randomized, controlled trial, assigning 61 lymphoma patients either to a control group (CG; N = 31) or to a 36-week intervention (IG; N = 30), consisting of sensorimotor-, endurance- and strength training twice a week. Primary end point was QOL; secondary end points included movement coordination, endurance, strength and therapy-induced side-effects. Intergroup comparison revealed improved QOL- (delta(T1-T0); P = 0.03) and PNP-related deep sensitivity in the IG: 87.5% were able to reduce the symptom, compared with 0% in the CG (P < 0.001). Significant differences in the change of balance control could be found between the groups, with the IG improving while the CG steadily declined (monopedal static delta(T3-T0); P = 0.03; dynamic delta(T3-T0); P = 0.007; perturbed mono-delta(T3-T0); P = 0.009 and bipedal delta(T3-T0); P = 0.006), failed attempts (monopedal static delta(T3-T0); P = 0.02, dynamic delta(T3-T0); P < 0.001and perturbed delta(T3-T0); P = 0.006) and improved time to regain balance (delta(T3-T0); P = 0.04). Moreover, the change in the aerobic performance level (delta(T3-T0); P = 0.05) and additional amount of exercise carried out per week [metabolic equivalent (MET); P = 0.02] differed significantly across groups. Exercise, especially sensorimotor training, is a feasible and promising method to support cancer patients during therapy. It improves patients QOL, reduces restrictions from side-effects such as PNP and improves patients' balance control, physical performance level and mobility.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Streckmann, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kneis, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Leifert, J. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumann, F. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleber, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ihorst, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herich, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruessinger, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gollhofer, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bertz, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-447422
DOI:	10.1093/annonc/mdt568
Journal or Publication Title:	Ann. Oncol.
Volume:	25
Number:	2
Page Range:	S. 493 - 500
Date:	2014
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1569-8041
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CANCER; PREVENTION; MANAGEMENT; NEUROPATHY; TRIAL Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44742