Universität zu Köln

Filss, Christian P., Stoffels, Gabriele, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Sabel, Michael, Wittsack, Hans J., Coenen, Heinz H., Shah, Nadim J., Herzog, Hans and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2014). Histogram analysis reveals a better delineation of tumor volume from background in F-18-FET PET compared to CBV maps in a hybrid PET-MR studie in gliomas. Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc. Equip., 734. S. 175 - 179. AMSTERDAM: ELSEVIER. ISSN 1872-9576

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Abstract

Anatomical imaging with magnetic resonance imaging (MRI) is currently the method of first choice for diagnostic investigation of glial tumors. However, different MR sequences may over- or underestimate tumor size and thus it may not be possible to delineate tumor from adjacent brain. In order to compensate this confinement additonal MR sequences like perfusion weighted MRI (PWI) with regional cerebral blood volume (rCBV) or positron emission tomography (PET) with aminoacids are used to gain further information. Recent studies suggest that both of theses image modalities provide similar diagnostic information. For comparison tumor to brain ratios (TBR) with mean and maximum values are frequently used but results from different studies can often not be checked against each other. Furthermore, especially the maximum TBR in rCBV is at risk to be falsified by artifacts (e.g. blood vessels). These confinements are reduced by the use of histograms since all information of the VOIs are equally displayed. In this study we measured and compared the intersection of tumor and reference tissue histograms in F-18-FET PET and rCBV maps in glioma patients. Methods: Twenty-seven glioma patients with contrast enhancing lesion on T1-weighted MR images were investigated using static F-18-FET PET and rCBV in MRI using a PET-MR hybrid scanner. In all patients diagnosis was confirmed histologically (7 grade II gliomas, 6 grade III gliomas and 14 grade IV gliomas). We generated a set of tumor and reference tissue Volumes-of-Interest (VOIs) based on T1 weighted images in MRI with the tumor VOI defined by contrast enhancement and transferred these VOIs to the corresponding F-18-FET PET scans and rCBV maps. From these VOIs we generated tumor and reference tissue histograms with a unity of one for each curve integral and measured the proportion of the area under the tumor curve that falls into the reference curve for F-18-FET PET and rCBV maps for each patient. Results: The mean proportion of the area under the tumor curve that falls into the reference curve was smaller in FET PET than in rCBV maps (13.1 +/- 19.5% vs. 45.0 +/- 21.3%; p < 0.001). Conclusions: Measuring the intersection of tumor and reference tissue histograms in F-18-FET PET and rCBV maps based on identical VOIs defined in anatomical images with tumor marked by contrast enhancement in T1-weighted images can easily be performed and indicates that tumor volume can better be discriminated from background in F-18-FET PET compared to rCBV in MRI. With this approach artefacts (e.g. blood vessels) impair the results to a lesser degree compared to the mean and especially maximal TBRs which are often used when comparing these two image modalities. (C) 2013 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Filss, Christian P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffels, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Sabel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittsack, Hans J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Coenen, Heinz H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herzog, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-448553
DOI:	10.1016/j.nima.2013.09.003
Journal or Publication Title:	Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc. Equip.
Volume:	734
Page Range:	S. 175 - 179
Date:	2014
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1872-9576
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CEREBRAL BLOOD-VOLUME; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; PERFUSION MRI; BRAIN; RECURRENCE Multiple languages Instruments & Instrumentation; Nuclear Science & Technology; Physics, Nuclear; Physics, Particles & Fields Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44855