Universität zu Köln

Neumann, Sascha and Noegel, Angelika A. (2014). Nesprins in Cell Stability and Migration. In: Advances in Experimental Medicine and Biology, S. 491 - 505. BERLIN: SPRINGER-VERLAG BERLIN. ISBN 978-1-4899-8032-8; 978-1-4899-8031-1

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Abstract

Nesprins are a family of proteins that are primarily known for their localization along the nuclear envelope. Together with inner nuclear membrane SUN proteins, they form the core of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex that traverses both nuclear membranes to connect the cytoplasm and the nuclear interior. Based on their structure and interactions, Nesprins integrate the nucleus into the cytoskeleton of a cell. Mutations in Nesprins have been identified in a group of human diseases that have been summarized as laminopathies. Cellular functions of the Nesprins and recent studies on different cancer types additionally draw interest on Nesprins in the field of cancer research. Here we summarize recent findings about the structural arrangements of Nesprins along the nuclear envelope, and highlight Nesprin functions in basic cellular processes like maintenance of nuclear shape and size, and of nuclear and cellular or cytoskeletal organization, centrosomal positioning, cell migration, and signal transduction. In summary, Nesprins are involved in critical cellular processes, which in case of malfunction contribute to the formation of cancer and might represent novel targets in cancer diagnosis or for therapeutic intervention.

Item Type:	Book Section, Proceedings Item or annotation in a legal commentary
Creators:	Creators Email ORCID ORCID Put Code Neumann, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Noegel, Angelika A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-448969
DOI:	10.1007/978-1-4899-8032-8_22
Title of Book:	Advances in Experimental Medicine and Biology
Series Name:	Adv.Exp.Med.Biol.
Volume:	773
Page Range:	S. 491 - 505
Date:	2014
Publisher:	SPRINGER-VERLAG BERLIN
Place of Publication:	BERLIN
ISSN:	2214-8019
ISBN:	978-1-4899-8032-8; 978-1-4899-8031-1
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUCLEAR-MEMBRANE PROTEIN; ACTIN FLOW; ENVELOPE; ARCHITECTURE; COMPLEXES; SIZE; MICROTUBULES; ANCHORAGE; BINDING; SYNE-1 Multiple languages Oncology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44896