Universität zu Köln

Hamann, Nina, Brueggemann, Gert-Peter and Niehoff, Anja ORCID: 0000-0002-4165-0929 (2014). Topographical variations in articular cartilage and subchondral bone of the normal rat knee are age-related. Ann. Anat.-Anat. Anz., 196 (5). S. 278 - 286. MUNICH: ELSEVIER GMBH. ISSN 1618-0402

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Abstract

In osteoarthritis animal models the rat knee is one of the most frequently investigated joint. However, it is unknown whether topographical variations in articular cartilage and subchondral bone of the normal rat knee exist and how they are linked or influenced by growth and maturation. Detailed knowledge is needed in order to allow interpretation and facilitate comparability of published osteoarthritis studies. For the first time, the present study maps topographical variations in cartilage thickness, cartilage compressive properties and subchondral bone microarchitecture between the medial and lateral tibial compartment of normal growing rat knees (7 vs. 13 weeks). Thickness and compressive properties (aggregate modulus) of cartilage were determined and the subchondral bone was analyzed by micro-computed tomography. We found that articular cartilage thickness is initially homogenous in both compartments, but then differentiates during growth and maturation resulting in greater cartilage thickness in the medial compartment in the 13-week-old animals. Cartilage compressive properties did not vary between the two sites independently of age. In both age-groups, subchondral plate thickness as well as trabecular bone volume ratio and trabecular thickness were greater in the medial compartment. While a high porosity of subchondral bone plate with a high topographical variation (medial/lateral) could be observed in the 7-week-old animals, the porosity was reduced and was accompanied by a reversion in topographical variation when reaching maturity. Our findings highlight that there is a considerable topographical variation in articular cartilage and subchondral bone within the normal rat knee in relation to the developmental status. (C) 2014 Elsevier GmbH. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hamann, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Brueggemann, Gert-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Niehoff, Anja UNSPECIFIED orcid.org/0000-0002-4165-0929 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-449742
DOI:	10.1016/j.aanat.2014.04.006
Journal or Publication Title:	Ann. Anat.-Anat. Anz.
Volume:	196
Number:	5
Page Range:	S. 278 - 286
Date:	2014
Publisher:	ELSEVIER GMBH
Place of Publication:	MUNICH
ISSN:	1618-0402
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDENTATION STIFFNESS; FUNCTIONAL ADAPTATION; MECHANICAL-PROPERTIES; RUNNING EXERCISE; TRABECULAR BONE; MICRO-CT; OSTEOARTHRITIS; MODEL; JOINT; PROGRESSION Multiple languages Anatomy & Morphology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44974