Keusekotten, Kirstin, Bade, Veronika N., Meyer-Teschendorf, Katrin, Sriramachandran, Annie Miriam, Fischer-Schrader, Katrin ORCID: 0000-0003-4532-8918, Krause, Anke, Horst, Christiane, Schwarz, Guenter ORCID: 0000-0002-2118-9338, Hofmann, Kay, Dohmen, R. Juergen and Praefcke, Gerrit J. K. (2014). Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO. Biochem. J., 457. S. 207 - 215. LONDON: PORTLAND PRESS LTD. ISSN 1470-8728

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Abstract

RNF4 (RING finger protein 4) is a STUbL [SUMO (small ubiquitin-related modifier)-targeted ubiquitin ligase] controlling PML (promyelocytic leukaemia) nuclear bodies, DNA double strand break repair and other nuclear functions. In the present paper, we describe that the sequence and spacing of the SIMs (SUMO-interaction motifs) in RNF4 regulate the avidity-driven recognition of substrate proteins carrying SUMO chains of variable length.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Keusekotten, KirstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bade, Veronika N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer-Teschendorf, KatrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sriramachandran, Annie MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer-Schrader, KatrinUNSPECIFIEDorcid.org/0000-0003-4532-8918UNSPECIFIED
Krause, AnkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horst, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwarz, GuenterUNSPECIFIEDorcid.org/0000-0002-2118-9338UNSPECIFIED
Hofmann, KayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dohmen, R. JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Praefcke, Gerrit J. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-450535
DOI: 10.1042/BJ20130753
Journal or Publication Title: Biochem. J.
Volume: 457
Page Range: S. 207 - 215
Date: 2014
Publisher: PORTLAND PRESS LTD
Place of Publication: LONDON
ISSN: 1470-8728
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
UBIQUITIN E3 LIGASE; PROMYELOCYTIC LEUKEMIA; BINDING MOTIF; DNA-DAMAGE; SNURF RNF4; RAR-ALPHA; PML; IDENTIFICATION; SUMOYLATION; UBIQUITYLATIONMultiple languages
Biochemistry & Molecular BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/45053

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