Hos, Deniz and Cursiefen, Claus (2014). Lymphatic Vessels in the Development of Tissue and Organ Rejection. In: Advances in Anatomy Embryology and Cell Biology, S. 119 - 142. BERLIN: SPRINGER-VERLAG BERLIN. ISBN 978-3-7091-1645-6; 978-3-7091-1646-3

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Abstract

The lymphatic vascular system-amongst other tasks-is critically involved in the regulation of adaptive immune responses as it provides an important route for APC trafficking to secondary lymphatic organs. In this context, the cornea, which is the transparent and physiologically avascular windscreen of the eye, has served as an excellent in vivo model to study the role of the blood and lymphatic vasculature in mediating allogenic immune responses after transplantation. Especially the mouse model of high-risk corneal transplantation, where corneal avascularity is abolished by a severe inflammatory stimulus prior to keratoplasty, allows for comparison to other transplantations performed in primarily vascularized tissues and solid organs. Using this model, we recently demonstrated that especially lymphatic vessels, but not blood vessels, define the high-risk status of vascularized corneas and that anti( lymph) angiogenic treatment significantly promotes corneal allograft survival. Since evidence for lymphangiogenesis and its potential association with graft rejection is nowadays also present in solid organ transplantation, studies are currently addressing the potential benefits of anti(lymph) angiogenic treatment as a novel therapeutic concept also in solid organ grafting with promising initial results.

Item Type: Book Section, Proceedings Item or annotation in a legal commentary
Creators:
CreatorsEmailORCIDORCID Put Code
Hos, DenizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cursiefen, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-450808
DOI: 10.1007/978-3-7091-1646-3_10
Title of Book: Advances in Anatomy Embryology and Cell Biology
Series Name: Adv. Anat. Embyrol. Cell Biol.
Volume: 214
Page Range: S. 119 - 142
Date: 2014
Publisher: SPRINGER-VERLAG BERLIN
Place of Publication: BERLIN
ISSN: 0301-5556
ISBN: 978-3-7091-1645-6; 978-3-7091-1646-3
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ENDOTHELIAL GROWTH-FACTOR; RISK CORNEAL TRANSPLANTATION; DENDRITIC CELL-MIGRATION; VASCULARIZED HUMAN CORNEAS; GRAFT-SURVIVAL; FACTOR RECEPTOR-3; IMMUNE PRIVILEGE; INFLAMMATORY NEOVASCULARIZATION; INHIBITS LYMPHANGIOGENESIS; INDIRECT RECOGNITIONMultiple languages
Anatomy & Morphology; Cell BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/45080

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