Lennertz, Leonhard, Wagner, Michael ORCID: 0000-0003-2589-6440, Grabe, Hans Joergen, Franke, Petra E., Guttenthaler, Vera, Rampacher, Friederike, Schulze-Rauschenbach, Svenja, Vogeley, Andrea, Benninghoff, Jens, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364, Pukrop, Ralf, Klosterkoetter, Joachim, Falkai, Peter ORCID: 0000-0003-2873-8667, Maier, Wolfgang and Moessner, Rainald (2014). 5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option. Eur. Neuropsychopharmacol., 24 (1). S. 86 - 95. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1873-7862

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Abstract

A role of the HTR3A-E genes in obsessive-compulsive disorder (OCD) can be expected based on promising effects of 5-HT3 receptor antagonists as adjunctive treatment of OCD. We therefore genotyped six common coding or promoter variants within the HTR3A-E genes in a case-control-sample consisting of N=236 OCD patients and N=310 control subjects and in N=58 parent-child-trios. Given the heterogeneous OCD phenotype, we also investigated OCD symptom dimensions and cognitive endophenotypes in subsamples. OCD patients scoring high for the washing subtype were significantly more likely to carry the c.256G-allele of the HTR3E variant rs7627615 (p=0.0001) as compared to OCD patients low for this symptom dimension. Visual organization was impaired in OCD patients and unaffected relatives as compared to healthy control subjects and carriers of the HTR3E c.256G/c.256G-genotype performed significantly

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lennertz, LeonhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
Grabe, Hans JoergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franke, Petra E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guttenthaler, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rampacher, FriederikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulze-Rauschenbach, SvenjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vogeley, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benninghoff, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDorcid.org/0000-0002-6022-2364UNSPECIFIED
Pukrop, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klosterkoetter, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falkai, PeterUNSPECIFIEDorcid.org/0000-0003-2873-8667UNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moessner, RainaldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-452112
DOI: 10.1016/j.euroneuro.2013.07.003
Journal or Publication Title: Eur. Neuropsychopharmacol.
Volume: 24
Number: 1
Page Range: S. 86 - 95
Date: 2014
Publisher: ELSEVIER SCIENCE BV
Place of Publication: AMSTERDAM
ISSN: 1873-7862
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SEROTONIN REUPTAKE INHIBITORS; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; NEUROPSYCHOLOGICAL PERFORMANCE; SCHIZOPHRENIA-PATIENTS; 1ST-DEGREE RELATIVES; GENETIC ASSOCIATION; SYMPTOM DIMENSIONS; ONDANSETRON; AUGMENTATIONMultiple languages
Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/45211

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