Universität zu Köln

Popovych, Oleksandr and Tass, Peter A. (2014). Control of abnormal synchronization in neurological disorders. Front. Neurol., 5. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-2295

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Abstract

In the nervous system, synchronization processes play an important role, e.g., in the context of information processing and motor control. However, pathological, excessive synchronization may strongly impair brain function and is a hallmark of several neurological disorders. This focused review addresses the question of how an abnormal neuronal synchronization can specifically be counteracted by invasive and non-invasive brain stimulation as, for instance, by deep brain stimulation for the treatment of Parkinson's disease, or by acoustic stimulation for the treatment of tinnitus. On the example of coordinated reset (CR) neuromodulation, we illustrate how insights into the dynamics of complex systems contribute to successful model-based approaches, which use methods from synergetics, non-linear dynamics, and statistical physics, for the development of novel therapies for normalization of brain function and synaptic connectivity. Based on the intrinsic multistability of the neuronal populations induced by spike timing-dependent plasticity (STDP), CR neuromodulation utilizes the mutual interdependence between synaptic connectivity and dynamics of the neuronal networks in order to restore more physiological patterns of connectivity via desynchronization of neuronal activity. The very goal is to shift the neuronal population by stimulation from an abnormally coupled and synchronized state to a desynchronized regime with normalized synaptic connectivity, which significantly outlasts the stimulation cessation, so that long-lasting therapeutic effects can be achieved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Popovych, Oleksandr UNSPECIFIED UNSPECIFIED UNSPECIFIED Tass, Peter A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-452156
DOI:	10.3389/fneur.2014.00268
Journal or Publication Title:	Front. Neurol.
Volume:	5
Date:	2014
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-2295
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP-BRAIN-STIMULATION; HIGH-FREQUENCY STIMULATION; COORDINATED RESET NEUROMODULATION; TIMING-DEPENDENT PLASTICITY; SPINAL-CORD STIMULATION; INCREASED EEG POWER; SUBTHALAMIC NUCLEUS; PARKINSONS-DISEASE; PATHOLOGICAL SYNCHRONIZATION; NEURONAL-ACTIVITY Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45215