Antsiferova, Maria, Martin, Caroline, Huber, Marcel ORCID: 0000-0003-3821-2378, Feyerabend, Thorsten B., Foerster, Anja, Hartmann, Karin ORCID: 0000-0002-4595-8226, Rodewald, Hans-Reimer, Hohl, Daniel and Werner, Sabine ORCID: 0000-0001-7397-8710 (2013). Mast Cells Are Dispensable for Normal and Activin-Promoted Wound Healing and Skin Carcinogenesis. J. Immunol., 191 (12). S. 6147 - 6156. BETHESDA: AMER ASSOC IMMUNOLOGISTS. ISSN 1550-6606

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Abstract

The growth and differentiation factor activin A is a key regulator of tissue repair, inflammation, fibrosis, and tumorigenesis. However, the cellular targets, which mediate the different activin functions, are still largely unknown. In this study, we show that activin increases the number of mature mast cells in mouse skin in vivo. To determine the relevance of this finding for wound healing and skin carcinogenesis, we mated activin transgenic mice with CreMaster mice, which are characterized by Cre recombinase-mediated mast cell eradication. Using single-and double-mutant mice, we show that loss of mast cells neither affected the stimulatory effect of overexpressed activin on granulation tissue formation and reepithelialization of skin wounds nor its protumorigenic activity in a model of chemically induced skin carcinogenesis. Furthermore, mast cell deficiency did not alter wounding-induced inflammation and new tissue formation or chemically induced angiogenesis and tumorigenesis in mice with normal activin levels. These findings reveal that mast cells are not major targets of activin during wound healing and skin cancer development and also argue against nonredundant functions of mast cells in wound healing and skin carcinogenesis in general.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Antsiferova, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huber, MarcelUNSPECIFIEDorcid.org/0000-0003-3821-2378UNSPECIFIED
Feyerabend, Thorsten B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foerster, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartmann, KarinUNSPECIFIEDorcid.org/0000-0002-4595-8226UNSPECIFIED
Rodewald, Hans-ReimerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hohl, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Werner, SabineUNSPECIFIEDorcid.org/0000-0001-7397-8710UNSPECIFIED
URN: urn:nbn:de:hbz:38-470050
DOI: 10.4049/jimmunol.1301350
Journal or Publication Title: J. Immunol.
Volume: 191
Number: 12
Page Range: S. 6147 - 6156
Date: 2013
Publisher: AMER ASSOC IMMUNOLOGISTS
Place of Publication: BETHESDA
ISSN: 1550-6606
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TRANSGENIC MICE; DEFICIENT MICE; TISSUE-REPAIR; INFLAMMATION; MORPHOGENESIS; KIT; EXPRESSION; GROWTH; CANCER; ROLESMultiple languages
ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/47005

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