Universität zu Köln

Nourmohammad, Armita, Held, Torsten ORCID: 0000-0002-1131-1950 and Laessig, Michael (2013). Universality and predictability in molecular quantitative genetics. Curr. Opin. Genet. Dev., 23 (6). S. 684 - 694. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0380

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Abstract

Molecular traits, such as gene expression levels or protein binding affinities, are increasingly accessible to quantitative measurement by modern high-throughput techniques. Such traits measure molecular functions and, from an evolutionary point of view, are important as targets of natural selection. We review recent developments in evolutionary theory and experiments that are expected to become building blocks of a quantitative genetics of molecular traits. We focus on universal evolutionary characteristics: these are largely independent of a trait's genetic basis, which is often at least partially unknown. We show that universal measurements can be used to infer selection on a quantitative trait, which determines its evolutionary mode of conservation or adaptation. Furthermore, universality is closely linked to predictability of trait evolution across lineages. We argue that universal trait statistics extends over a range of cellular scales and opens new avenues of quantitative evolutionary systems biology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nourmohammad, Armita UNSPECIFIED UNSPECIFIED UNSPECIFIED Held, Torsten UNSPECIFIED orcid.org/0000-0002-1131-1950 UNSPECIFIED Laessig, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-470571
DOI:	10.1016/j.gde.2013.11.001
Journal or Publication Title:	Curr. Opin. Genet. Dev.
Volume:	23
Number:	6
Page Range:	S. 684 - 694
Date:	2013
Publisher:	CURRENT BIOLOGY LTD
Place of Publication:	LONDON
ISSN:	1879-0380
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FACTOR-BINDING SITES; ADAPTIVE EVOLUTION; ASEXUAL POPULATIONS; STATISTICAL PHYSICS; ESCHERICHIA-COLI; ANTIBIOTIC-RESISTANCE; STABILIZING SELECTION; CLONAL INTERFERENCE; NATURAL-SELECTION; ADAPTATION Multiple languages Cell Biology; Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47057