Universität zu Köln

Muether, Philipp S., Hermann, Manuel M., Droege, Katharina, Kirchhof, Bernd and Fauser, Sascha (2013). Long-term Stability of Vascular Endothelial Growth Factor Suppression Time Under Ranibizumab Treatment in Age-Related Macular Degeneration. Am. J. Ophthalmol., 156 (5). S. 989 - 994. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-1891

Full text not available from this repository.

Abstract

PURPOSE: To determine intra-individual long-term stability of vascular endothelial growth factor (VEGF) suppression time in eyes with neovascular age-related macular degeneration (AMD) treated with ranibizumab. DESIGN: Nonrandomized, prospective clinical study. METHODS: Eighty-three eyes of 83 patients with neovascular A.MD undergoing intravitreal ranibizumab injections were included in the study. A total of 859 aqueous humor specimens were taken before each intravitreal ranibizumab injection. Vascular endothelial growth factor A was measured by multiplex bead analysis. RESULTS: Ranibizumab resulted in complete VEGF suppression within a mean period of 36.4 days (standard deviation +/- 6.7 days; range, 26-69 days). Intra-individual suppression time was stable within a period of up to 3 years. Among 859 VEGF measurements, only 5 (0.58%) deviated from this pattern. Nonsuppressed VEGF levels did not differ significantly between baseline and recurrence (68.0 pg/mL vs 69.3 pg/mL) and did not correlate with choroidal neovascularization size and lesion type. CONCLUSIONS: Both the long-term stability and the broad range of individual suppression times after ranibizumab injections would allow and justify adjustment of continuous injections individually in order to achieve permanent VEGF suppression in patients. ((C) 2013 by Elsevier Inc. All rights reserved.)

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Muether, Philipp S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hermann, Manuel M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Droege, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-472500
DOI:	10.1016/j.ajo.2013.06.020
Journal or Publication Title:	Am. J. Ophthalmol.
Volume:	156
Number:	5
Page Range:	S. 989 - 994
Date:	2013
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1879-1891
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AQUEOUS-HUMOR LEVELS; VITREOUS LEVELS; BEVACIZUMAB; CYTOKINES Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47250