Frampton, Matthew, da Silva Filho, Miguel Inacio, Broderick, Peter ORCID: 0000-0002-8348-5829, Thomsen, Hauke ORCID: 0000-0001-5951-3116, Foersti, Asta, Vijayakrishnan, Jayaram ORCID: 0000-0002-8284-2249, Cooke, Rosie, Enciso-Mora, Victor, Hoffmann, Per, Noethen, Markus M., Lloyd, Amy, Holroyd, Amy, Eisele, Lewin, Joeckel, Karl-Heinz, Ponader, Sabine, von Strandmann, Elke Pogge, Lightfoot, Tracy, Roman, Eve, Lake, Annette, Montgomery, Dorothy, Jarrett, Ruth F., Swerdlow, Anthony J., Engert, Andreas, Hemminki, Kari and Houlston, Richard S. (2013). Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma. Nat. Commun., 4. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P = 1.14 x 10(-12), odds ratio (OR) = 1.26) and 6q23.3 (rs7745098; P = 3.42 x 10(-9), OR = 1.21). rs3806624 localizes 5' to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Frampton, MatthewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
da Silva Filho, Miguel InacioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broderick, PeterUNSPECIFIEDorcid.org/0000-0002-8348-5829UNSPECIFIED
Thomsen, HaukeUNSPECIFIEDorcid.org/0000-0001-5951-3116UNSPECIFIED
Foersti, AstaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vijayakrishnan, JayaramUNSPECIFIEDorcid.org/0000-0002-8284-2249UNSPECIFIED
Cooke, RosieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Enciso-Mora, VictorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmann, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noethen, Markus M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lloyd, AmyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holroyd, AmyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eisele, LewinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Joeckel, Karl-HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ponader, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Strandmann, Elke PoggeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lightfoot, TracyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roman, EveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lake, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montgomery, DorothyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jarrett, Ruth F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Swerdlow, Anthony J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engert, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hemminki, KariUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Houlston, Richard S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-474568
DOI: 10.1038/ncomms3549
Journal or Publication Title: Nat. Commun.
Volume: 4
Date: 2013
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENOME-WIDE ASSOCIATION; CHROMATIN STATES; T-BET; CELLS; ANNOTATION; SUSCEPTIBILITY; EXPRESSION; SCALE; LOCI; TOOLMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/47456

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