Universität zu Köln

Bonfig, Walter, Molz, Katharina, Woelfle, Joachim, Hofer, Sabine E., Hauffa, Berthold P., Schoenau, Eckhard, Golembowski, Sven, Wudy, Stefan A. and Holl, Reinhard W. (2013). Metabolic Safety of Growth Hormone in Type 1 Diabetes and Idiopathic Growth Hormone Deficiency. J. Pediatr., 163 (4). S. 1095 - 1103. NEW YORK: MOSBY-ELSEVIER. ISSN 1097-6833

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Abstract

Objective To evaluate metabolic consequences of growth hormone (GH) treatment in children with type 1 diabetes. Study design This study is an analysis of metabolic changes in 37 patients with childhood-onset GH deficiency and type 1 diabetes, documented in the Diabetes Patienten Verlaufsdocumentationsystem database. Main outcome measures were changes in hemoglobin A1c and daily insulin requirements during GH therapy in children with GH deficiency and type 1 diabetes compared with a large cohort of adolescents with type 1 diabetes. Results Thirty-seven patients with type 1 diabetes and a diagnosis of idiopathic GH deficiency after onset of diabetes were compared with 48 856 patients with type 1 diabetes. After adjustment for age, sex, duration of diabetes, and migration background, a significant difference in mean daily insulin requirement was seen between the 2 groups (1.0 IU/kg/day in subjects with GH deficiency and type 1 diabetes vs 0.85 IU/kg/day in controls; P < .01) and height-SDS (-2.0 in subjects with GH deficiency and diabetes vs +0.03 in controls; P < .0001). There was no significant between-group difference in hemoglobin A1 concentration, however (8.1% +/- 1.4% in patients with GH deficiency and type 1 diabetes vs 8.2% +/- 1.7% in those with type 1 diabetes only; P > .05). Conclusion An increased daily insulin requirement should be considered in patients with type 1 diabetes treated with GH. With adequate adaptation of insulin dosage, metabolic control is not impaired during GH treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bonfig, Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Molz, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Woelfle, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Hofer, Sabine E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hauffa, Berthold P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Golembowski, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Wudy, Stefan A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holl, Reinhard W. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-475032
DOI:	10.1016/j.jpeds.2013.04.045
Journal or Publication Title:	J. Pediatr.
Volume:	163
Number:	4
Page Range:	S. 1095 - 1103
Date:	2013
Publisher:	MOSBY-ELSEVIER
Place of Publication:	NEW YORK
ISSN:	1097-6833
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHILDREN; ADOLESCENTS; GLUCOSE; MELLITUS; PROTEIN Multiple languages Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47503