Universität zu Köln

Amit, M., Yen, T. C., Liao, C. T., Binenbaum, Y., Chaturvedi, P., Agarwal, J. P., Kowalski, L. P., Ebrahimi, A., Clark, J. R., Cernea, C. R., Brandao, S. J., Kreppel, M., Zoeller, J., Fliss, D., Bachar, G., Shpitzer, T., Bolzoni, V. A., Patel, P. R., Jonnalagadda, S., Robbins, K. T., Shah, J. P., Patel, S. G. and Gil, Ziv (2013). Clinical Nodal Stage is a Significant Predictor of Outcome in Patients with Oral Cavity Squamous Cell Carcinoma and Pathologically Negative Neck Metastases: Results of the International Consortium for Outcome Research. Ann. Surg. Oncol., 20 (11). S. 3575 - 3582. NEW YORK: SPRINGER. ISSN 1068-9265

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Abstract

We aimed to study the importance of clinical N classification (cN) in a subgroup of patients with oral cavity squamous cell carcinoma (OSCC) and pathologically negative neck nodes (pN-). A total of 2,258 patients from 11 cancer centers who underwent neck dissection for OSCC (1990-2011) had pN- disease. The median follow-up was 44 months. 5-year overall survival (OS), disease-specific survival (DSS), disease free survival, local control, locoregional control, and distant metastasis rates were calculated by the Kaplan-Meier method. cN classification and tumor, node, metastasis classification system staging variables were subjected to multivariate analysis. A total of 345 patients were preoperatively classified as cN+ and 1,913 were classified as cN-. The 5-year OS and DSS of cN- patients were 73.6 and 82.2 %, respectively. The 5-year OS and DSS of cN+ patients were 64.9 and 76.9 %, respectively (p < 0.0001 each). A cN+ classification was a significant predictor of worse OS (p = 0.03) and DSS (p = 0.016), regardless of treatment, depth of invasion, or extent of neck dissection. cN classification was associated with recurrence-free survival (p = 0.01) and locoregional (neck and primary tumor) control (p = 0.004), but not with local (p = 0.19) and distant (p = 0.06) recurrence rates. Clinical evidence of neck metastases is an independent predictor of outcome, even in patients with pN- nodes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Amit, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yen, T. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liao, C. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Binenbaum, Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chaturvedi, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Agarwal, J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kowalski, L. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ebrahimi, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Clark, J. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cernea, C. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brandao, S. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fliss, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachar, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shpitzer, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bolzoni, V. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Patel, P. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jonnalagadda, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Robbins, K. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Patel, S. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gil, Ziv UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-475131
DOI:	10.1245/s10434-013-3044-0
Journal or Publication Title:	Ann. Surg. Oncol.
Volume:	20
Number:	11
Page Range:	S. 3575 - 3582
Date:	2013
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1068-9265
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UPPER AERODIGESTIVE TRACT; LOCALLY ADVANCED HEAD; POSTOPERATIVE RADIOTHERAPY; CERVICAL METASTASES; CANCER; CHEMOTHERAPY; DISSECTION; FAILURE; MICROMETASTASES; METAANALYSIS Multiple languages Oncology; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47513