Herbrecht, R., Cernohous, P., Engert, A., Le Gouill, S., Macdonald, D., Machida, C., Myint, H., Saleh, A., Singer, J., Wilhelm, M. and van der Jagt, R. (2013). Comparison of pixantrone-based regimen (CPOP-R) with doxorubicin-based therapy (CHOP-R) for treatment of diffuse large B-cell lymphoma. Ann. Oncol., 24 (10). S. 2618 - 2624. OXFORD: OXFORD UNIV PRESS. ISSN 0923-7534

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Abstract

Pixantrone is an aza-anthracenedione with enhanced, preclinical antitumor activity and reduced cardiotoxicity compared with doxorubicin. We compared the efficacy and toxic effect of CPOP-R (substituting pixantrone for doxorubicin) against CHOP-R in untreated, diffuse large B-cell lymphoma (DLBCL) patients. The primary objective was to demonstrate non-inferiority of CPOP-R by complete response/complete response unconfirmed (CR/CRu) rate. The CR/CRu rate for CPOP-R was 75% versus 84% for CHOP-R. Three-year overall survival was lower for CPOP-R (69% versus 85%) (P = 0.029). Median progression-free survival (PFS) was not reached for CPOP-R and was 40 months for CHOP-R [HR 95% confidence interval (CI) = 1.02 (0.60, 1.76), P = 0.934]. Fewer CPOP-R patients developed congestive heart failure (CHF) (0% versus 6%, P = 0.120), >= 20% declines in ejection fraction (2% versus 17%, P = 0.004), or elevations in troponin-T (P = 0.003). CPOP-R is an active regimen with modestly lower response rates than CHOP-R but similar PFS and event-free survival. This study demonstrates a substantially lower cardiotoxicity of pixantrone compared with doxorubicin when used as first-line therapy in DLBCL.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Herbrecht, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cernohous, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engert, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Gouill, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Macdonald, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Machida, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Myint, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saleh, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Singer, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilhelm, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Jagt, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-475240
DOI: 10.1093/annonc/mdt289
Journal or Publication Title: Ann. Oncol.
Volume: 24
Number: 10
Page Range: S. 2618 - 2624
Date: 2013
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 0923-7534
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NON-HODGKINS-LYMPHOMA; ELDERLY-PATIENTS; INTENSIVE CHEMOTHERAPY; AZA-ANTHRACENEDIONE; CYCLOPHOSPHAMIDE; VINCRISTINE; PREDNISONE; BBR-2778Multiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/47524

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