Universität zu Köln

Krakstad, Camilla ORCID: 0000-0002-0174-8139, Birkeland, Even, Seidel, Danila ORCID: 0000-0003-4388-3117, Kusonmano, Kanthida, Petersen, Kjell, Mjos, Siv, Hoivik, Erling A., Wik, Elisabeth, Halle, Mari Kylleso, Oyan, Anne M., Kalland, Karl-Henning ORCID: 0000-0003-4486-2334, Werner, Henrica Maria Johanna, Trovik, Jone and Salvesen, Helga (2012). High-Throughput Mutation Profiling of Primary and Metastatic Endometrial Cancers Identifies KRAS, FGFR2 and PIK3CA to Be Frequently Mutated. PLoS One, 7 (12). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background: Despite being the most common pelvic gynecologic malignancy in industrialized countries, no targeted therapies are available for patients with metastatic endometrial carcinoma. In order to improve treatment, underlying molecular characteristics of primary and metastatic disease must be explored. Methodology/Principal Findings: We utilized the mass spectrometric-based mutation detection technology OncoMap to define the types and frequency of point somatic mutations in endometrial cancer. 67 primary tumors, 15 metastases corresponding to 7 of the included primary tumors and 11 endometrial cancer cell lines were screened for point mutations in 28 known oncogenes. We found that 27 (40.3%) of 67 primary tumors harbored one or more mutations with no increase in metastatic lesions. FGFR2, KRAS and PIK3CA were consistently the most frequently mutated genes in primary tumors, metastatic lesions and cell lines. Conclusions/Significance: Our results emphasize the potential for targeting FGFR2, KRAS and PIK3CA mutations in endometrial cancer for development of novel therapeutic strategies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Krakstad, Camilla UNSPECIFIED orcid.org/0000-0002-0174-8139 UNSPECIFIED Birkeland, Even UNSPECIFIED UNSPECIFIED UNSPECIFIED Seidel, Danila UNSPECIFIED orcid.org/0000-0003-4388-3117 UNSPECIFIED Kusonmano, Kanthida UNSPECIFIED UNSPECIFIED UNSPECIFIED Petersen, Kjell UNSPECIFIED UNSPECIFIED UNSPECIFIED Mjos, Siv UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoivik, Erling A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wik, Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Halle, Mari Kylleso UNSPECIFIED UNSPECIFIED UNSPECIFIED Oyan, Anne M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalland, Karl-Henning UNSPECIFIED orcid.org/0000-0003-4486-2334 UNSPECIFIED Werner, Henrica Maria Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Trovik, Jone UNSPECIFIED UNSPECIFIED UNSPECIFIED Salvesen, Helga UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-476443
DOI:	10.1371/journal.pone.0052795
Journal or Publication Title:	PLoS One
Volume:	7
Number:	12
Date:	2012
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LUNG ADENOCARCINOMA; COLORECTAL CANCERS; SOMATIC MUTATIONS; CARCINOMA; BRAF; INHIBITION; PTEN; VEMURAFENIB; ACTIVATION; GENOME Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47644