Universität zu Köln

von Tresckow, Bastian and Engert, Andreas (2012). The emerging role of PET in Hodgkin lymphoma patients receiving autologous stem cell transplant. Expert Rev. Hematol., 5 (5). S. 483 - 487. LONDON: EXPERT REVIEWS. ISSN 1747-4086

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Abstract

Evaluation of: Cocorocchio E, Peccatori F, Vanazzi A et al. High-dose chemotherapy in relapsed or refractory Hodgkin lymphoma patients: a reappraisal of prognostic factors. Hematol. Oncol. doi:10.1002/hon.2014 (2012) (Epub ahead of print). High-dose chemotherapy followed by autologous stem cell transplant (ASCT) is the standard therapy for patients with relapsed or refractory Hodgkin lymphoma. Several analyses have reported risk factors for a poor outcome after ASCT to allow for an individualized treatment, but there is no consensus on how the outcome in high-risk patients might be improved. A recent study by Cocorocchio et al. analyzes risk factors in 97 patients who received ASCT. Besides the established risk factor remission status after induction, result of positron emission tomography before and after transplant was the most important prognostic factor for progression-free survival and overall survival. This result is in line with other retrospective analyses and might allow for the selection of high-risk patients who should receive alternative treatment approaches, such as second-line salvage therapy, tandem ASCT, new drugs or maintenance therapy. Randomized trials characterizing the best therapeutic option for high-risk patients are highly warranted.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Tresckow, Bastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-481205
DOI:	10.1586/EHM.12.41
Journal or Publication Title:	Expert Rev. Hematol.
Volume:	5
Number:	5
Page Range:	S. 483 - 487
Date:	2012
Publisher:	EXPERT REVIEWS
Place of Publication:	LONDON
ISSN:	1747-4086
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; INVOLVED-FIELD RADIOTHERAPY; FDG-PET; COMBINATION CHEMOTHERAPY; PROGNOSTIC SCORE; PREDICTIVE-VALUE; DISEASE; 2ND-LINE; SURVIVAL; ABVD Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48120