Universität zu Köln

Niemann, Catherin and Horsley, Valerie (2012). Development and homeostasis of the sebaceous gland. Semin. Cell Dev. Biol., 23 (8). S. 928 - 937. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1084-9521

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Abstract

The important role of epidermal appendages especially the sebaceous gland has only recently been recognized. In particular, it has been convincingly shown that normal development and maintenance of the sebaceous gland are required for skin homeostasis since atrophic sebaceous glands and disturbances in sebaceous lipid composition result in major defects of the physiological barrier and maintenance of the skin. Consequently, it is important to unravel the signaling network controlling proper sebaceous lineage differentiation in mammalian skin and to understand the underlying mechanisms leading to severe skin diseases, including abnormal proliferation and differentiation of the gland, defects of the lipid metabolism and barrier, as well as sebaceous tumor formation. Over the last years, results from transgenic and knock out mouse models manipulating distinct signaling pathways in the skin as well as the detailed analysis of human sebaceous gland-derived cell lines provided new insights into crucial mediators balancing proliferation and differentiation of the sebaceous gland. Here, we discuss our current knowledge of in vivo mechanisms of sebaceous gland development, maintenance and disorders and highlight recent contributions to the field of sebaceous gland biology. (C) 2012 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Niemann, Catherin UNSPECIFIED UNSPECIFIED UNSPECIFIED Horsley, Valerie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-481283
DOI:	10.1016/j.semcdb.2012.08.010
Journal or Publication Title:	Semin. Cell Dev. Biol.
Volume:	23
Number:	8
Page Range:	S. 928 - 937
Date:	2012
Publisher:	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Place of Publication:	LONDON
ISSN:	1084-9521
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EPIDERMAL STEM-CELLS; PROLIFERATOR-ACTIVATED RECEPTOR; HAIR FOLLICLE MORPHOGENESIS; TRANSGENIC MICE; HUMAN SEBOCYTES; BETA-CATENIN; MOUSE EPIDERMIS; SKIN TUMORS; C-MYC; SCARRING ALOPECIA Multiple languages Cell Biology; Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48128