Universität zu Köln

Scola, N., Skrygan, M., Wieland, U., Kreuter, A. and Gambichler, T. (2012). Altered gene expression in squamous cell carcinoma arising from congenital unilateral linear porokeratosis. Clin. Exp. Dermatol., 37 (7). S. 781 - 786. HOBOKEN: WILEY-BLACKWELL. ISSN 0307-6938

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Abstract

Congenital unilateral linear porokeratosis (CULP) is a rare disorder of keratinization that shares clinical and molecular similarities with psoriasis. It also has an increased risk for malignant transformation to cutaneous squamous cell carcinoma (SCC). We investigated the expression of psoriasin, human beta-defensin-2, cathelicidin antimicrobial peptide/LL-37, e-cadherin, involucrin, p16INK4a, p53, cyclin D1 and microchromosome maintenance protein 7 in healthy skin and in lesions of psoriasis, CULP and SCC from the same patient. p16INK4a was overexpressed in CULP but not in the subsequent SCC. Psoriasin was overexpressed in psoriasis, CULP and SCC compared with healthy skin. Speculatively, p16INK4a and psoriasin could be involved in the pathogenesis of CULP. Moreover, psoriasin may play a role in the malignant transformation of CULP to SCC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Scola, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Skrygan, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieland, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreuter, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gambichler, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-481863
DOI:	10.1111/j.1365-2230.2012.04393.x
Journal or Publication Title:	Clin. Exp. Dermatol.
Volume:	37
Number:	7
Page Range:	S. 781 - 786
Date:	2012
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	0307-6938
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTIMICROBIAL PEPTIDES; MALIGNANCY; PSORIASIS; SKIN Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48186