Universität zu Köln

Vehreschild, J. J., Broeckelmann, P. J., Bangard, C., Verheyen, J., Vehreschild, M. J. G. T., Michels, G., Wisplinghoff, H. and Cornely, O. A. (2012). Pandemic 2009 influenza A(H1N1) virus infection coinciding with invasive pulmonary aspergillosis in neutropenic patients. Epidemiol. Infect., 140 (10). S. 1848 - 1853. NEW YORK: CAMBRIDGE UNIV PRESS. ISSN 1469-4409

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Abstract

In patients receiving anti-neoplastic chemotherapy, the impact of influenza on the incidence of invasive pulmonary aspergillosis (IPA) remains unknown. We matched data of the Cologne Cohort of Neutropenic Patients (CoCoNut) with records from the Institute for Virology and compared the findings to historical data. During the pandemic, we diagnosed influenza A(H1N1) in five patients with malignancies and febrile neutropenia refractory to antibiotic therapy. Probable IPA was diagnosed in three of these patients on the grounds of typical computed tomography morphology and microbiological results. Three of five patients receiving remission-induction chemotherapy for acute myeloid leukaemia developed aspergillosis although receiving posaconazole prophylaxis. In the 3 years before the influenza pandemic, only 2/77 patients of this group developed infection. Infection with influenza A(H1N1) may increase the risk for invasive aspergillosis in neutropenic patients. Pulmonary aspergillosis is an important additional differential diagnosis in neutropenic influenza patients with pneumonia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vehreschild, J. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Broeckelmann, P. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bangard, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Verheyen, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, M. J. G. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Michels, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wisplinghoff, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, O. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-482326
DOI:	10.1017/S0950268811002603
Journal or Publication Title:	Epidemiol. Infect.
Volume:	140
Number:	10
Page Range:	S. 1848 - 1853
Date:	2012
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	NEW YORK
ISSN:	1469-4409
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FUNGAL-INFECTIONS; PROPHYLAXIS; PNEUMONIA Multiple languages Public, Environmental & Occupational Health; Infectious Diseases Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48232