Universität zu Köln

Pfister, Roman, Michels, Guido, Sharp, Stephen J., Luben, Robert, Wareham, Nick J. and Khaw, Kay-Tee (2012). Resting heart rate and incident heart failure in apparently healthy men and women in the EPIC-Norfolk study. Eur. J. Heart Fail., 14 (10). S. 1163 - 1171. HOBOKEN: WILEY. ISSN 1879-0844

Full text not available from this repository.

Abstract

Increasing levels of resting heart rate are associated with increased risk of developing hypertension and cardiovascular disease, and seem to play a role in the progression of heart failure. The shape of the association between resting heart rate and risk of developing heart failure has not been examined in healthy individuals of the general population. Hazard ratios (HRs) of heart failure comparing categories of resting heart rate [5160 b.p.m. (reference), 6170 b.p.m., 7180 b.p.m., 8190 b.p.m., and 91100 b.p.m.] were calculated in apparently healthy men (9805) and women (12 321) aged 3979 participating in the oEuropean Prospective Investigation into Cancer and Nutrition' (EPIC) study in Norfolk. During a mean follow-up of 12.9 years, 1356 incident cases of heart failure occurred. In participants without potential heart rate-modifying medication, age- and sex-adjusted incidence rates of heart failure were 3.3, 3.7, 4.0, 5.1, and 5.5 per 1000 person-years for increasing categories of resting heart rate; compared with the reference category, HRs and 95 confidence intervals (CI) for increasing categories of resting heart rate were 1.08 (0.881.34), 1.17 (0.941.46), 1.39 (1.081.79), and 1.42 (1.002.03), respectively, in multivariable analysis adjusting for age, sex, body mass index, systolic blood pressure, prevalent diabetes, cholesterol concentration, social class, educational level, smoking, and physical activity. Within the reference range of resting heart rate (50100 b.p.m.) each 10 b.p.m. increase was associated with an 11 increase in hazard of heart failure in multivariable analysis. The results did not change materially after adjusting for myocardial infarction and coronary heart disease events during follow up (1.12, 1.061.18). Resting heart rate shows a graded association with hazard of heart failure in apparently healthy men and women which is not mediated by coronary heart disease. Further study is needed to examine the underlying mechanisms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pfister, Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED Michels, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharp, Stephen J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Luben, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Wareham, Nick J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Khaw, Kay-Tee UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-482357
DOI:	10.1093/eurjhf/hfs104
Journal or Publication Title:	Eur. J. Heart Fail.
Volume:	14
Number:	10
Page Range:	S. 1163 - 1171
Date:	2012
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1879-0844
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MYOCARDIAL-ISCHEMIA; PHYSICAL-ACTIVITY; RISK-FACTOR; PATHOPHYSIOLOGY; MORTALITY; HYPERTENSION; TACHYCARDIA; IVABRADINE; PREVENTION; PREDICTION Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48235