Universität zu Köln

Mathew, Sam J., Rembold, Martina and Leptin, Maria (2011). Role for Traf4 in Polarizing Adherens Junctions as a Prerequisite for Efficient Cell Shape Changes. Mol. Cell. Biol., 31 (24). S. 4978 - 4994. WASHINGTON: AMER SOC MICROBIOLOGY. ISSN 0270-7306

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Abstract

Apical constriction of epithelial cells is a widely used morphogenetic mechanism. In the Drosophila embryo, the apical constrictions that internalize the mesoderm are controlled by the transcription factor Twist and require intact adherens junctions and a contractile acto-myosin network. We find that adherens junctions in constricting mesodermal cells undergo extensive remodeling. A Twist target gene encoding a member of the tumor necrosis factor (TNF) receptor-associated factor (TRAF) family, Traf4, is involved in this process. While TRAFs are best known for their functions in inflammatory responses, Traf4 appears to have a different role, and its mechanism of action is poorly understood. We show that Traf4 is required for efficient apical constriction during ventral furrow formation and for proper localization of Armadillo to the apical position in constricting cells. Traf4 and Armadillo interact with each other physically and functionally. Traf4 acts in a TNF receptor-and Jun N-terminal protein kinase (JNK)-independent manner to fine-tune the assembly of adherens junctions in the invaginating mesodermal cells.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mathew, Sam J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rembold, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Leptin, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-484410
DOI:	10.1128/MCB.05542-11
Journal or Publication Title:	Mol. Cell. Biol.
Volume:	31
Number:	24
Page Range:	S. 4978 - 4994
Date:	2011
Publisher:	AMER SOC MICROBIOLOGY
Place of Publication:	WASHINGTON
ISSN:	0270-7306
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language N-TERMINAL KINASE; DROSOPHILA EMBRYO; SIGNALING PATHWAY; EPITHELIAL POLARITY; SPATIAL EXPRESSION; GENE-EXPRESSION; PROTEIN-KINASE; FEEDBACK LOOP; RHO-GTPASE; GASTRULATION Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48441