Universität zu Köln

Robijn, Stef, Hoppe, Bernd, Vervaet, Benjamin A., D'Haese, Patrick C. and Verhulst, Anja (2011). Hyperoxaluria: a gut-kidney axis? Kidney Int., 80 (11). S. 1146 - 1159. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1523-1755

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Abstract

Hyperoxaluria leads to urinary calcium oxalate (CaOx) supersaturation, resulting in the formation and retention of CaOx crystals in renal tissue. CaOx crystals may contribute to the formation of diffuse renal calcifications (nephrocalcinosis) or stones (nephrolithiasis). When the innate renal defense mechanisms are suppressed, injury and progressive inflammation caused by these CaOx crystals, together with secondary complications such as tubular obstruction, may lead to decreased renal function and in severe cases to end-stage renal failure. For decades, research on nephrocalcinosis and nephrolithiasis mainly focused on both the physicochemistry of crystal formation and the cell biology of crystal retention. Although both have been characterized quite well, the mechanisms involved in establishing urinary supersaturation in vivo are insufficiently understood, particularly with respect to oxalate. Therefore, current therapeutic strategies often fail in their compliance or effectiveness, and CaOx stone recurrence is still common. As the etiology of hyperoxaluria is diverse, a good understanding of how oxalate is absorbed and transported throughout the body, together with a better insight in the regulatory mechanisms, is crucial in the setting of future treatment strategies of this disorder. In this review, the currently known mechanisms of oxalate handling in relevant organs will be discussed in relation to the different etiologies of hyperoxaluria. Furthermore, future directions in the treatment of hyperoxaluria will be covered. Kidney International (2011) 80, 1146-1158; doi:10.1038/ki.2011.287; published online 24 August 2011

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Robijn, Stef UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoppe, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Vervaet, Benjamin A. UNSPECIFIED UNSPECIFIED UNSPECIFIED D'Haese, Patrick C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Verhulst, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-484912
DOI:	10.1038/ki.2011.287
Journal or Publication Title:	Kidney Int.
Volume:	80
Number:	11
Page Range:	S. 1146 - 1159
Date:	2011
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1523-1755
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language URINARY OXALATE EXCRETION; BACTERIUM OXALOBACTER-FORMIGENES; APICAL CL-/HCO3-EXCHANGER; SLC26A6 ANION-EXCHANGER; Y GASTRIC BYPASS; STONE FORMERS; INTESTINAL OXALATE; PROXIMAL TUBULE; DIETARY OXALATE; RENAL-FAILURE Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48491