Xia, Xin R., Monteiro-Riviere, Nancy A., Mathur, Sanjay, Song, Xuefeng, Xiao, Lisong, Oldenberg, Steven J., Fadeel, Bengt and Riviere, Jim E. (2011). Mapping the Surface Adsorption Forces of Nanomaterials in Biological Systems. ACS Nano, 5 (11). S. 9074 - 9082. WASHINGTON: AMER CHEMICAL SOC. ISSN 1936-086X

Full text not available from this repository.

Abstract

The biological surface adsorption Index (BSAI) is a novel approach to characterize surface adsorption energy of nanomaterials that is the primary force behind nanoparticle aggregation, protein corona formation, and other complex interactions of nanomaterials within biological systems. Five quantitative nanodescriptors were obtained to represent the surface adsorption forces (hydrophobicity, hydrogen bond, polarity/polarizability, and lone-pair electrons) of the nanomaterial interaction with biological components. We have mapped the surface adsorption forces over 16 different nanomaterials. When the five-dimensional information of the nanodescriptors was reduced to two dimensions, the 16 nanomaterials were classified Into distinct clusters according their surface adsorption properties. BSAI nanodescriptors are Intrinsic properties of nanomaterials useful for quantitative structure-activity relationship (QSAR) model development. This Is the first success in quantitative characterization of the surface adsorption forces of nanomaterials in biological conditions, which could open a quantitative avenue in predictive nanomedicine development, risk assessment, and safety evaluation of nanomaterials.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Xia, Xin R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monteiro-Riviere, Nancy A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mathur, SanjayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Song, XuefengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xiao, LisongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oldenberg, Steven J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fadeel, BengtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riviere, Jim E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-486030
DOI: 10.1021/nn203303c
Journal or Publication Title: ACS Nano
Volume: 5
Number: 11
Page Range: S. 9074 - 9082
Date: 2011
Publisher: AMER CHEMICAL SOC
Place of Publication: WASHINGTON
ISSN: 1936-086X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CARBON NANOTUBES; PHYSICOCHEMICAL PROPERTIES; NANOPARTICLE SIZE; AGGREGATION; VALIDATION; ACTIVATION; FIBRINOGEN; TOXICITY; PROTEINS; RATESMultiple languages
Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, MultidisciplinaryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48603

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item