Universität zu Köln

Galldiks, Norbert ORCID: 0000-0002-2485-1796, Kracht, Lutz W., Dunkl, Veronika, Ullrich, Roland T., Vollmar, Stefan, Jacobs, Andreas H., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Schroeter, Michael (2011). Imaging of Non- or Very Subtle Contrast-Enhancing Malignant Gliomas with [C-11]-Methionine Positron Emission Tomography. Mol. Imaging, 10 (6). S. 453 - 460. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1536-0121

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Abstract

In patients with World Health Organization (WHO) grade III glioma with a lack of or minimal (< 1 cm(3)) magnetic resonance imaging (MRI) contrast enhancement, the volume of the metabolically active part of the tumor was assessed by [C-11]-methionine positron emission tomography (MET-PET). Eleven patients with WHO grade III gliomas underwent MET-PET and MRI (contrast-enhanced T-1- and T-2-weighted images). To calculate the volumes in cubic centimeters, threshold-based volume of interest analyses of the metabolically active tumor (MET uptake index >= 1.3), contrast enhancement, and the T-2 lesion were performed after coregistration of all images. In all patients, the metabolically active tumor volume was larger than the volume of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) enhancement (20.8 +/- 18.8 vs 0.29 +/- 0.25 cm(3); p < .001). With the exception of one patient, the volumes of contrast enhancement were located within the metabolically active tumor volume. In contrast, in the majority of patients, MET uptake overlapped with the T-2 lesion and reached beyond it (in 10 of 12 MRIs/MET-PET scans). The present data suggest that in patients with WHO grade III glioma with minimal or a lack of contrast enhancement, MET-PET delineates metabolically active tumor tissue. These findings support the use of combined PET-MRI with radiolabeled amino acids leg, MET) for the delineating of the true extent of active tumor in the diagnosis and treatment planning of patients with gliomas.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Kracht, Lutz W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dunkl, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Ullrich, Roland T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vollmar, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Jacobs, Andreas H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-486743
DOI:	10.2310/7290.2011.00014
Journal or Publication Title:	Mol. Imaging
Volume:	10
Number:	6
Page Range:	S. 453 - 460
Date:	2011
Publisher:	SAGE PUBLICATIONS INC
Place of Publication:	THOUSAND OAKS
ISSN:	1536-0121
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGH-GRADE GLIOMAS; BLOOD-VOLUME MAPS; C-11-METHIONINE PET; TARGET DELINEATION; TUMOR GRADE; MRI; ENHANCEMENT; IMPROVES; SURGERY; BIOPSY Multiple languages Biochemical Research Methods; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48674