Tischler, Verena ORCID: 0000-0002-6673-8329, Pfeifer, Marco, Hausladen, Silke, Schirmer, Uwe, Bonde, Anne-Katrine, Kristiansen, Glen, Sos, Martin L., Weder, Walter, Moch, Holger, Altevogt, Peter and Soltermann, Alex (2011). L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer. Mol. Cancer, 10. LONDON: BIOMED CENTRAL LTD. ISSN 1476-4598

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Abstract

Background: The L1 cell adhesion molecule (L1CAM) is potentially involved in epithelial-mesenchymal transition (EMT). EMT marker expression is of prognostic significance in non-small cell lung cancer (NSCLC). The relevance of L1CAM for NSCLC is unclear. We investigated the protein expression of L1CAM in a cohort of NSCLC patients. L1CAM protein expression was correlated with clinico-pathological parameters including survival and markers of epithelial-mesenchymal transition. Results: L1CAM protein expression was found in 25% of squamous cell carcinomas and 24% of adenocarcinomas and correlated with blood vessel invasion and metastasis (p < 0.05). L1CAM was an independent predictor of survival in a multivariate analysis including pT, pN, and pM category, and tumor differentiation grade. L1CAM expression positively correlated with vimentin, beta-catenin, and slug, but inversely with E-cadherin (all p-values < 0.05). E-cadherin expression was higher in the tumor center than in the tumor periphery, whereas L1CAM and vimentin were expressed at the tumor-stroma interface. In L1CAM-negative A549 cells the L1CAM expression was upregulated and matrigel invasion was increased after stimulation with TGF-beta1. In L1CAM-positive SK-LU-1 and SK-LC-LL cells matrigel invasion was decreased after L1CAM siRNA knockdown. Conclusions: A subset of NSCLCs with vessel tropism and increased metastasis aberrantly expresses L1CAM. L1CAM is a novel prognostic marker for NSCLCs that is upregulated by EMT induction and appears to be instrumental for enhanced cell invasion.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Tischler, VerenaUNSPECIFIEDorcid.org/0000-0002-6673-8329UNSPECIFIED
Pfeifer, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hausladen, SilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schirmer, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonde, Anne-KatrineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kristiansen, GlenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sos, Martin L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weder, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moch, HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Altevogt, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soltermann, AlexUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-487368
DOI: 10.1186/1476-4598-10-127
Journal or Publication Title: Mol. Cancer
Volume: 10
Date: 2011
Publisher: BIOMED CENTRAL LTD
Place of Publication: LONDON
ISSN: 1476-4598
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ADHESION MOLECULE L1; EPITHELIAL-MESENCHYMAL TRANSITION; CARCINOMA CELLS; STEM-CELLS; E-CADHERIN; THERAPEUTIC ANTIBODIES; MALIGNANT-MELANOMA; COLORECTAL-CANCER; TUMOR PROGRESSION; OVARIAN-CARCINOMAMultiple languages
Biochemistry & Molecular Biology; OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48736

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