Pyrc, Krzysztof ORCID: 0000-0002-3867-7688, Strzyz, Paulina ORCID: 0000-0001-6086-1361, Milewska, Aleksandra, Golda, Anna, Schildgen, Oliver ORCID: 0000-0003-4297-9627 and Potempa, Jan (2011). Porphyromonas gingivalis enzymes enhance infection with human metapneumovirus in vitro. J. Gen. Virol., 92. S. 2324 - 2333. READING: SOC GENERAL MICROBIOLOGY. ISSN 0022-1317

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Abstract

Relatively recently discovered, human metapneumovirus (HMPV) is a human pathogen with worldwide prevalence, accounting for a substantial percentage of respiratory tract diseases. Concurrent viral and bacterial infections enable intricate mechanisms of cooperation between pathogens, which complicate the symptoms and outcome of the disease. Such bilateral interactions are based on the modulation of bacterial growth on epithelium pathologically altered during viral illness and the modulation of immune responses, as well as the enhancement of virus replication by bacterial virulence factors. This study showed that proteases produced by Porphyromonas gingivalis, a Gram-negative bacterium implicated in the development of periodontitis, named gingipains, facilitated HMPV replication in LLC-MK2 cells and may contribute to HMPV pathogenicity in patients with periodontitis. Gingipains at low nanomolar concentrations enabled HMPV replication and allowed virus propagation in vitro. In contrast to previously published data for influenza virus, however, Staphylococcus aureus proteases and human neutrophil elastase did not affect virus replication.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Pyrc, KrzysztofUNSPECIFIEDorcid.org/0000-0002-3867-7688UNSPECIFIED
Strzyz, PaulinaUNSPECIFIEDorcid.org/0000-0001-6086-1361UNSPECIFIED
Milewska, AleksandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Golda, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schildgen, OliverUNSPECIFIEDorcid.org/0000-0003-4297-9627UNSPECIFIED
Potempa, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-487850
DOI: 10.1099/vir.0.032094-0
Journal or Publication Title: J. Gen. Virol.
Volume: 92
Page Range: S. 2324 - 2333
Date: 2011
Publisher: SOC GENERAL MICROBIOLOGY
Place of Publication: READING
ISSN: 0022-1317
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RESPIRATORY-TRACT DISEASE; PERIODONTAL HEALTH-STATUS; ASPIRATION PNEUMONIA; CYSTEINE PROTEINASES; FUSION PROTEIN; STAPHYLOCOCCUS-AUREUS; TREPONEMA-DENTICOLA; INFLUENZA PNEUMONIA; RSV BRONCHIOLITIS; GENETIC DIVERSITYMultiple languages
Biotechnology & Applied Microbiology; VirologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48785

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