Universität zu Köln

Semrau, Robert, Temming, Susanne, Preuss, Simon Florian, Klussmann, Jens Peter, Guntinas-Lichius, Orlando ORCID: 0000-0001-9671-0784 and Mueller, Rolf-Peter (2011). Definitive Radiochemotherapy of Advanced Head and Neck Cancer with Carboplatin and Paclitaxel A Phase II Study. Strahlenther. Onkol., 187 (10). S. 645 - 651. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-099X

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Abstract

Purpose: To report outcome and toxicity of concurrent radiochemotherapy with carboplatin and paclitaxel in advanced squamous cell carcinomas of the oropharynx and hypopharynx. Patients and Methods: Advanced inoperable carcinomas of the oropharynx and hypopharynx were treated with either hyper-fractionated, accelerated radiotherapy (50.0 Gy/2.0 with concomitant boost to 69.2 Gy/1.6) or conventional fractionated radiotherapy (70.2-72 Gy/1.8) concurrent with paclitaxel 40 mg/m(2) and carboplatin AUC 1 weekly for 6 weeks. Acute and long-term toxicity was measured according to WHO- and CTC-criteria. Results: A total of 84 patients were included between 2000 and 2008. Median follow-up time of patients alive was 36 months. Conventionally fractionated radiotherapy was given to 16 patients, while 68 patients were treated with concomitant boost. Finally, 88.1% of patients received full dose paclitaxel. Acute mucositis >= grade 3 was present in 51.2% of patients, while 6% of patients experienced >= grade 3 leucopenia and thrombopenia. A supportive gastric feeding tube was implanted in 89.1% of patients. Overall survival after 2 years was 46.3%, progression-free survival after 2 years was 41.0%. There was no significant survival difference between the different radiotherapy protocols. Conclusion: Concomitant carboplatin and paclitaxel is feasible and effective in advanced carcinomas of the head and neck.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Semrau, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Temming, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Preuss, Simon Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Klussmann, Jens Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Guntinas-Lichius, Orlando UNSPECIFIED orcid.org/0000-0001-9671-0784 UNSPECIFIED Mueller, Rolf-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-488008
DOI:	10.1007/s00066-011-1111-7
Journal or Publication Title:	Strahlenther. Onkol.
Volume:	187
Number:	10
Page Range:	S. 645 - 651
Date:	2011
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1439-099X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOCALLY ADVANCED HEAD; SQUAMOUS-CELL CARCINOMA; ACCELERATED RADIOTHERAPY; HYPERFRACTIONATED RADIOTHERAPY; CONCURRENT CARBOPLATIN; RADIATION-THERAPY; UNRESECTABLE HEAD; INOPERABLE HEAD; CISPLATIN; TRIAL Multiple languages Oncology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48800