Universität zu Köln

Ruge, Maximilian I., Kickingereder, Philipp, Grau, Stefan, Hoevels, Mauritius, Treuer, Harald and Sturm, Volker (2011). Stereotactic biopsy combined with stereotactic (125)iodine brachytherapy for diagnosis and treatment of locally recurrent single brain metastases. J. Neuro-Oncol., 105 (1). S. 109 - 119. NEW YORK: SPRINGER. ISSN 1573-7373

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Abstract

This paper reports on stereotactic biopsy combined with stereotactic 125 iodine brachytherapy (SBT) for locally recurrent, previously irradiated cerebral metastases, focusing on feasibility, complications, cerebral disease control, and survival. All patients with suspected locally recurrent metastases detected by MRI were selected for this combined procedure. After stereotactic biopsy, all patients with a verified vital tumor underwent SBT (50 Gy surface dose applied for 42 days) during the same surgical procedure. Histological results of biopsy, complications, treatment response, local and distant disease control, and survival were evaluated. Thirty patients underwent stereotactic biopsy, and 27 were treated with SBT for histologically proved tumor recurrence. There was no treatmen-trelated mortality, and morbidity was transient and low (6.6%). Median survival was 14.8 months. After one year the actuarial incidence of local and distant relapse was 6.7 and 45.5%, respectively. There was no grade 3 or 4 CNS toxicity, even among the 18.5% of patients with tumor >30 mm. For these patients stereotactic biopsy seems to be a safe and valuable means of differentiating between radiation-induced tissue changes and tumor recurrence/progression. SBT is a safe, minimally invasive, and highly effective treatment option for cerebral disease control and survival. Furthermore, it can be performed during the same stereotactic operation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ruge, Maximilian I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kickingereder, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Grau, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoevels, Mauritius UNSPECIFIED UNSPECIFIED UNSPECIFIED Treuer, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Sturm, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-488525
DOI:	10.1007/s11060-011-0571-z
Journal or Publication Title:	J. Neuro-Oncol.
Volume:	105
Number:	1
Page Range:	S. 109 - 119
Date:	2011
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1573-7373
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIFFERENTIATING TUMOR RECURRENCE; INTERSTITIAL I-125 RADIOSURGERY; GAMMA-KNIFE SURGERY; LOW-GRADE GLIOMAS; CEREBRAL METASTASES; SURGICAL RESECTION; RADIATION-THERAPY; RANDOMIZED-TRIAL; SEEDS; SUPRATENTORIAL Multiple languages Oncology; Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48852