Universität zu Köln

Grubert, Christiane, Hurlemann, Rene ORCID: 0000-0003-2628-565X, Bewernick, Bettina H., Kayser, Sarah, Hadrysiewicz, Barbara, Axmacher, Nikolai ORCID: 0000-0002-0475-6492, Sturm, Volker and Schlaepfer, Thomas E. (2011). Neuropsychological safety of nucleus accumbens deep brain stimulation for major depression: Effects of 12-month stimulation. World J. Biol. Psychiatry, 12 (7). S. 516 - 528. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1814-1412

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Abstract

Objectives. Deep brain stimulation (DBS) to the nucleus accumbens (NAcc-DBS) has antidepressant effects in patients suffering from treatment-resistant depression (TRD). However, limited information exists regarding the impact of NAcc-DBS on cognitive functioning. The aim of this study was to examine whether NAcc-DBS in patients with TRD has any cognitive effects. Methods. A comprehensive neuropsychological battery was administered to 10 patients with TRD before onset of bilateral NAcc-DBS and after 1 year of DBS stimulation. Neuropsychological testing covered the domains of attention, learning and memory, executive functions, visual perception, and language. Performance was analyzed at baseline and after 1 year of continuous DBS. Results. No evidence was found for cognitive decline following NAcc-DBS comparing test results after 1 year of NAcc-DBS with baseline. However, significantly improved cognitive performance on tests of attention, learning and memory, executive functions and visual perception was found. In addition, there was a general trend towards cognitive enhancement from below average to average performance. These procognitive effects were independent of the antidepressant effects of NAcc-DBS or changes in NAcc-DBS parameters. Conclusions. These results not only support cognitive safety of NAcc-DBS but also stress its beneficial role in augmenting cognitive performance in patients with TRD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grubert, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Hurlemann, Rene UNSPECIFIED orcid.org/0000-0003-2628-565X UNSPECIFIED Bewernick, Bettina H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kayser, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Hadrysiewicz, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Axmacher, Nikolai UNSPECIFIED orcid.org/0000-0002-0475-6492 UNSPECIFIED Sturm, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlaepfer, Thomas E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-488640
DOI:	10.3109/15622975.2011.583940
Journal or Publication Title:	World J. Biol. Psychiatry
Volume:	12
Number:	7
Page Range:	S. 516 - 528
Date:	2011
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1814-1412
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VAGUS NERVE-STIMULATION; GLOBUS-PALLIDUS; REPEATED ADMINISTRATIONS; PARKINSONS-DISEASE; MEMORY; REWARD; IMPROVEMENT; IMPAIRMENT; THERAPY; CORTEX Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48864