Universität zu Köln

Drebber, Uta, Madeja, Martin, Odenthal, Margarete, Wedemeyer, Inga, Moenig, Stefan P., Brabender, Jan, Bollschweiler, Elfriede, Hoelscher, Arnulf H., Schneider, Paul M., Dienes, Hans P. and Vallboehmer, Daniel (2011). beta-catenin and Her2/neu expression in rectal cancer: association with histomorphological response to neoadjuvant therapy and prognosis. Int. J. Colorectal Dis., 26 (9). S. 1127 - 1135. NEW YORK: SPRINGER. ISSN 0179-1958

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Abstract

Background Neoadjuvant treatment strategies have been developed to improve survival of patients with advanced rectal cancer. Since mainly patients with major histopathological response benefit from this therapy, predictive and prognostic markers are needed. We examined the association of beta-catenin and Her2/neu protein expression with histopathologic response to neoadjuvant radiochemotherapy and prognosis in patients with locally advanced rectal cancer. Methods Fifty-four patients (33 male; 21 female; median age 60.4 years) with locally advanced rectal cancer were included in this study. All patients received a neoadjuvant radiochemotherapy (50.4 Gy, 5-FU) followed by surgical resection. Histomorphologic regression was evaluated by Dworak and Cologne staging system. Major response was defined by Dworak classification when resected specimens contained less than 50% vital tumor cells (n=14) and by Cologne grading system when resected specimens contained less than 10% vital tumor cells (n=15). Intratumoral beta-catenin (nuclear/membranous) and Her2/neu (cytoplasmatic/membranous) expression was determined by immunohistochemistry in pre- and post-therapeutic specimens and correlated with clinicopathologic parameters. Results A significant association was detected between pretherapeutic membranous beta-catenin levels and response: patients with a lower beta-catenin protein expression showed significantly more often a major response compared with patients having high intratumoral protein levels (p=0.011). In addition, patients with a higher Her2/neu protein expression showed a significant survival benefit compared with patients having low intratumoral protein levels (5-year survival rate: 81% vs. low 41%; p=0.023). Conclusions The pre-therapeutic beta-catenin and Her2/neu protein expression seem to be valuable predictive and prognostic markers in the multimodality treatment of advanced rectal cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Drebber, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Madeja, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Odenthal, Margarete UNSPECIFIED UNSPECIFIED UNSPECIFIED Wedemeyer, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Moenig, Stefan P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brabender, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Bollschweiler, Elfriede UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoelscher, Arnulf H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Paul M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dienes, Hans P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vallboehmer, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-489300
DOI:	10.1007/s00384-011-1213-9
Journal or Publication Title:	Int. J. Colorectal Dis.
Volume:	26
Number:	9
Page Range:	S. 1127 - 1135
Date:	2011
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	0179-1958
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LYMPH-NODE METASTASES; COLORECTAL-CANCER; PREOPERATIVE CHEMORADIOTHERAPY; TUMOR-REGRESSION; POSTOPERATIVE CHEMORADIOTHERAPY; NEOPLASTIC PROGRESSION; RANDOMIZED-TRIAL; GENE-PRODUCT; RADIOCHEMOTHERAPY; RADIOTHERAPY Multiple languages Gastroenterology & Hepatology; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48930