Universität zu Köln

Rothe, Achim and Rubbert, Andrea (2011). Recombinant proteins in rheumatology - recent advances. New Biotech., 28 (5). S. 502 - 511. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1871-6784

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Abstract

New targeted anti-inflammatory drugs have revolutionized the therapeutic strategies in rheumatology. Recombinant DNA selection technologies have enabled the isolation and humanization of specific antibody fragments of any specificity that can be 'armed' to deliver effective anti-inflammatory 'payloads'. Antibodies and other targeted provide the opportunity to block key soluble mediators of inflammation in their milieu, or alternatively to block intracellular inflammation-triggering pathways by binding to an upstream cell-surface receptor. Designed proteins can be improved with respect to desired pharmacokinetic and pharmacodynamic effects. They facilitate the delivery of the required immunosuppressive effect. However, the individual extent of desired and undesired effects of a particular biologic therapy can be broader than initially predicted and requires careful evaluation during clinical trials. This review highlights advances in the application of recombinant antibody technology for novel biologic therapies in rheumatology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rothe, Achim UNSPECIFIED UNSPECIFIED UNSPECIFIED Rubbert, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-489485
DOI:	10.1016/j.nbt.2011.03.019
Journal or Publication Title:	New Biotech.
Volume:	28
Number:	5
Page Range:	S. 502 - 511
Date:	2011
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1871-6784
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language B-CELL DEPLETION; MONOCLONAL-ANTIBODY; IN-VITRO; THERAPEUTIC PROTEINS; AUTOIMMUNE-DISEASE; BIOLOGIC THERAPIES; CONTROLLED-TRIAL; FUSION PROTEIN; NEW-GENERATION; FC-RECEPTOR Multiple languages Biochemical Research Methods; Biotechnology & Applied Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48948