Bechdolf, Andreas, Mueller, Hendrik, Stuetzer, Hartmut, Wagner, Michael ORCID: 0000-0003-2589-6440, Maier, Wolfgang, Lautenschlager, Marion, Heinz, Andreas ORCID: 0000-0001-5405-9065, de Millas, Walter, Janssen, Birgit, Gaebel, Wolfgang, Michel, Tanja Maria, Schneider, Frank ORCID: 0000-0003-1557-7956, Lambert, Martin, Naber, Dieter, Bruene, Martin, Krueger-Oezguerdal, Seza, Wobrock, Thomas, Riedel, Michael and Klosterkoetter, Joachim (2011). Rationale and Baseline Characteristics of PREVENT: A Second-Generation Intervention Trial in Subjects At-Risk (Prodromal) of Developing First-Episode Psychosis Evaluating Cognitive Behavior Therapy, Aripiprazole, and Placebo for the Prevention of Psychosis. Schizophr. Bull., 37. S. S111 - 11. OXFORD: OXFORD UNIV PRESS. ISSN 1745-1701

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Abstract

Antipsychotics, cognitive behavioral therapy (CBT), and omega-3-fatty acids have been found superior to control conditions as regards prevention of psychosis in people at-risk of first-episode psychosis. However, no large-scale trial evaluating the differential efficacy of CBT and antipsychotics has been performed yet. In PREVENT, we evaluate CBT, aripiprazole, and clinical management (CM) as well as placebo and CM for the prevention of psychosis in a randomized, double-blind, placebo-controlled trial with regard to the antipsychotic intervention and a randomized controlled trial with regard to the CBT intervention with blinded ratings. The hypotheses are first that CBT and aripiprazole and CM are superior to placebo and CM and second that CBT is not inferior to aripiprazole and CM combined. The primary outcome is transition to psychosis. By November 2010, 156 patients were recruited into the trial. The subjects were substantially functionally compromised (Social and Occupational Functioning Assessment Scale mean score 52.5) and 78.3% presented with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition axis I comorbid diagnosis. Prior to randomization, 51.5% of the participants preferred to be randomized into the CBT arm, whereas only 12.9% preferred pharmacological treatment. First, assessments of audiotaped treatment sessions confirmed the application of CBT-specific skills in the CBT condition and the absence of those in CM. The overall quality rating of the CBT techniques applied in the CBT condition was good. When the final results of the trial are available, PREVENT will substantially expand the current limited evidence base for best clinical practice in people at-risk (prodromal) of first-episode psychosis.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bechdolf, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stuetzer, HartmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lautenschlager, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinz, AndreasUNSPECIFIEDorcid.org/0000-0001-5405-9065UNSPECIFIED
de Millas, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janssen, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaebel, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michel, Tanja MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, FrankUNSPECIFIEDorcid.org/0000-0003-1557-7956UNSPECIFIED
Lambert, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Naber, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruene, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krueger-Oezguerdal, SezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wobrock, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klosterkoetter, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-489854
DOI: 10.1093/schbul/sbr083
Journal or Publication Title: Schizophr. Bull.
Volume: 37
Page Range: S. S111 - 11
Date: 2011
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1745-1701
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ULTRA-HIGH-RISK; INDICATED PREVENTION; FOLLOW-UP; SCHIZOPHRENIA; PEOPLE; PREDICTION; MODEL; SCALE; VULNERABILITY; RELIABILITYMultiple languages
PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48985

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