Universität zu Köln

Kreppel, Matthias, Drebber, Uta, Wedemeyer, Inga, Eich, Hans-Theodor, Backhaus, Tim, Zoeller, Joachim E. and Scheer, Martin (2011). Podoplanin expression predicts prognosis in patients with oral squamous cell carcinoma treated with neoadjuvant radiochemotherapy. Oral Oncol., 47 (9). S. 873 - 879. AMSTERDAM: ELSEVIER. ISSN 1879-0593

Full text not available from this repository.

Abstract

Despite new therapeutic approaches patients with advanced oral squamous cell carcinoma still have a dismal prognosis. The main factor contributing to this problem is locoregional failure due to a lack of response to treatment. Several trials have proven the effect of neoadjuvant radiochemotherapy followed by radical surgery in comparison to primary surgery followed by adjuvant radiochemotherapy. No reliable parameters have been identified so far to predict response to radiochemotherapy. The aim of our study was to assess whether podoplanin expression in pretreatment biopsies could serve as a biomarker to predict the host response to neoadjuvant radiochemotherapy. In this retrospective study, podoplanin expression was examined in a set of 63 patients with oral squamous cell carcinoma by immunohistochemistry. We analyzed associations between the level of podoplanin expression and various clinicopathologic parameters, including response to radiochemotherapy, clinical and histological N-status. Furthermore we evaluated the effects of these parameters on overall survival and on locoregional control in univariate and multivariate analysis. The chi(2)-test revealed that high expression of podoplanin in pretreatment biopsy material was associated with non-regression of the tumor (p = 0.013) and poor overall survival (p < 0.001). Five-year survival rates of 92.9% for patients with weak expression and 15.0% for high expression were revealed. Podoplanin expression was also significantly associated with ypN status (p = 0.004) and ypUICC status (p < 0.001). We concluded that podoplanin might serve as a factor to predict treatment response in oral squamous cell carcinoma treated with neoadjuvant platin-based radiochemotherapy as well as a prognostic factor for overall survival and locoregional control. (C) 2011 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Wedemeyer, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Eich, Hans-Theodor UNSPECIFIED UNSPECIFIED UNSPECIFIED Backhaus, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-490011
DOI:	10.1016/j.oraloncology.2011.06.508
Journal or Publication Title:	Oral Oncol.
Volume:	47
Number:	9
Page Range:	S. 873 - 879
Date:	2011
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1879-0593
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PLUS RADICAL SURGERY; TUMOR LYMPHANGIOGENESIS; CONCURRENT CHEMORADIOTHERAPY; ADVANCED HEAD; NECK CANCERS; CAVITY; CHEMOTHERAPY; METASTASIS; RESECTION; SURVIVAL Multiple languages Oncology; Dentistry, Oral Surgery & Medicine Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49001