Universität zu Köln

Klingberg, Stefan ORCID: 0000-0001-8081-7181, Wittorf, Andreas, Meisner, Christoph, Woelwer, Wolfgang, Wiedemann, Georg, Herrlich, Jutta, Bechdolf, Andreas, Mueller, Bernhard W., Sartory, Gudrun, Wagner, Michael ORCID: 0000-0003-2589-6440, Kircher, Tilo ORCID: 0000-0002-2514-2625, Koenig, Hans-Helmut, Engel, Corinna and Buchkremer, Gerhard (2010). Cognitive behavioural therapy versus supportive therapy for persistent positive symptoms in psychotic disorders: The POSITIVE Study, a multicenter, prospective, single-blind, randomised controlled clinical trial. Trials, 11. LONDON: BMC. ISSN 1745-6215

Full text not available from this repository.

Abstract

Background: It has been demonstrated that cognitive behavioural therapy (CBT) has a moderate effect on symptom reduction and on general well being of patients suffering from psychosis. However, questions regarding the specific efficacy of CBT, the treatment safety, the cost-effectiveness, and the moderators and mediators of treatment effects are still a major issue. The major objective of this trial is to investigate whether CBT is specifically efficacious in reducing positive symptoms when compared with non-specific supportive therapy (ST) which does not implement CBT-techniques but provides comparable therapeutic attention. Methods/Design: The POSITIVE study is a multicenter, prospective, single-blind, parallel group, randomised clinical trial, comparing CBT and ST with respect to the efficacy in reducing positive symptoms in psychotic disorders. CBT as well as ST consist of 20 sessions altogether, 165 participants receiving CBT and 165 participants receiving ST. Major methodological aspects of the study are systematic recruitment, explicit inclusion criteria, reliability checks of assessments with control for rater shift, analysis by intention to treat, data management using remote data entry, measures of quality assurance (e.g. on-site monitoring with source data verification, regular query process), advanced statistical analysis, manualized treatment, checks of adherence and competence of therapists. Research relating the psychotherapy process with outcome, neurobiological research addressing basic questions of delusion formation using fMRI and neuropsychological assessment and treatment research investigating adaptations of CBT for adolescents is combined in this network. Problems of transfer into routine clinical care will be identified and addressed by a project focusing on cost efficiency. Discussion: This clinical trial is part of efforts to intensify psychotherapy research in the field of psychosis in Germany, to contribute to the international discussion on psychotherapy in psychotic disorders, and to help implement psychotherapy in routine care. Furthermore, the study will allow drawing conclusions about the mediators of treatment effects of CBT of psychotic disorders.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Klingberg, Stefan UNSPECIFIED orcid.org/0000-0001-8081-7181 UNSPECIFIED Wittorf, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Meisner, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Woelwer, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiedemann, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Herrlich, Jutta UNSPECIFIED UNSPECIFIED UNSPECIFIED Bechdolf, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Bernhard W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sartory, Gudrun UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Kircher, Tilo UNSPECIFIED orcid.org/0000-0002-2514-2625 UNSPECIFIED Koenig, Hans-Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Engel, Corinna UNSPECIFIED UNSPECIFIED UNSPECIFIED Buchkremer, Gerhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-490379
DOI:	10.1186/1745-6215-11-123
Journal or Publication Title:	Trials
Volume:	11
Date:	2010
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1745-6215
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEGATIVE SYNDROME SCALE; PERSECUTORY DELUSIONS; PSYCHOMETRIC PROPERTIES; SCHIZOPHRENIA; PSYCHOTHERAPY; INTERVENTION; RESISTANT; ALLIANCE; INSIGHT; MODELS Multiple languages Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49037