Universität zu Köln

Rey, Johannes W., Noetel, Andrea, Hardt, Aline, Canbay, Ali ORCID: 0000-0001-6069-7899, Alakus, Hakan, zur Hausen, Axel, Dienes, Hans Peter, Drebber, Uta and Odenthal, Margarete (2010). Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma 2 in patients with fatty liver diseases. World J. Gastroenterol., 16 (46). S. 5830 - 5838. PLEASANTON: BAISHIDENG PUBLISHING GROUP INC. ISSN 2219-2840

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Abstract

AIM: To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-gamma (PPAR gamma)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD). METHODS: DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n = 263) and AFLD (n = 100) were analyzed by Real-time polymerase chain reaction using allele-specific probes. RESULTS: In the NAFLD and the AFLD collective, 3% of the patients showed homozygous occurrence of the Ala12 PPAR gamma 2-allele, differing from only 1.5% cases in the healthy population. In NAFLD patients, a high incidence of the Ala12 mutant was not associated with the progression of fatty liver disease. However, we observed a significantly higher risk (odds ratio = 2.50, CI: 1.05-5.90, P = 0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory alterations. The linkage of the malfunctioning Ala12-positive PPAR gamma 2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of PPAR gamma 2 in progression of AFLD than of NAFLD. CONCLUSION: In AFLD patients, the Pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis. (C) 2010 Baishideng. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rey, Johannes W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Noetel, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Hardt, Aline UNSPECIFIED UNSPECIFIED UNSPECIFIED Canbay, Ali UNSPECIFIED orcid.org/0000-0001-6069-7899 UNSPECIFIED Alakus, Hakan UNSPECIFIED UNSPECIFIED UNSPECIFIED zur Hausen, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Dienes, Hans Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Odenthal, Margarete UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-490669
DOI:	10.3748/wjg.v16.i46.5830
Journal or Publication Title:	World J. Gastroenterol.
Volume:	16
Number:	46
Page Range:	S. 5830 - 5838
Date:	2010
Publisher:	BAISHIDENG PUBLISHING GROUP INC
Place of Publication:	PLEASANTON
ISSN:	2219-2840
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BODY-MASS INDEX; PPAR-GAMMA; NONALCOHOLIC STEATOHEPATITIS; HEPATIC STEATOSIS; SCORING SYSTEM; GENE; PPAR-GAMMA-2; INSULIN; OBESITY; IMPACT Multiple languages Gastroenterology & Hepatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49066