Universität zu Köln

Spuentrup, E., Jacobs, J. E., Kleimann, J. F., Wiethoff, A. J., Poggenborg, J., Brinker, G., Loehr, M., Hartmann, W. Moeller, Botnar, R. M., Emestus, R. I. and Lackner, K. J. (2010). High Spatial Resolution and High Contrast Visualization of Brain Arteries and Veins: Impact of Blood Pool Contrast Agent and Water-Selective Excitation Imaging at 3T. Rofo-Fortschr. Gebiet Rontgenstrahlen Bildgeb. Verfahr., 182 (12). S. 1097 - 1105. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-9010

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Abstract

Purpose To investigate a blood pool contrast agent and water-selective excitation imaging at 3T for high spatial and high contrast imaging of brain vessels including the veins Methods and Results 48 clinical patients (47 +/- 18years old) were included Based on clinical findings twenty-four patients received a single dose of standard extracellular Gadoterate-meglumine (Dotareme (R)) and 24 received the blood pool contrast agent Gadofosveset (Vasovist (R)) After finishing routine MR protocols, all patients were investigated with two high spatial resolution (0 15 mm(3) voxel size) gradient echo sequences in random order in the equilibrium phase (steadystate) as approved by the review board A standard RF-spoiled gradient-echo sequence (HR-SS TR/TE 5 1/2 3 msec, FA 30 degrees) and a fat-suppressed gradient-echo sequence with water-selective excitation (HR-FS 1331 binominal-pulse, TRITE 8 8/3 8 msec FA 30 degrees) The images were subjectively assessed (image quality with vessel contrast artifacts depiction of lesions) by two investigators and contrast-to-noise ratios (CNR) were compared using the Student's t-test The image quality and CNR in the HR-FS were significantly superior compared to the HR-SS for both contrast agents (p < 0 05) The CNR was also improved when using the blood pool agent but only to a minor extent while the subjective image quality was similar for both contrast agents Conclusion The utilized sequence with water-selective excitation improved image quality and CNR properties in high spatial resolution imaging of brain arteries and veins The used blood pool contrast agent improved the CNR only to a minor extent over the extracellular contrast agent

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Spuentrup, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jacobs, J. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleimann, J. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiethoff, A. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Poggenborg, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brinker, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Loehr, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, W. Moeller UNSPECIFIED UNSPECIFIED UNSPECIFIED Botnar, R. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Emestus, R. I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lackner, K. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-492066
DOI:	10.1055/s-0029-1245648
Journal or Publication Title:	Rofo-Fortschr. Gebiet Rontgenstrahlen Bildgeb. Verfahr.
Volume:	182
Number:	12
Page Range:	S. 1097 - 1105
Date:	2010
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1438-9010
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MAGNETIC-RESONANCE ANGIOGRAPHY; CEREBRAL VENOUS THROMBOSIS; CORONARY MR-ANGIOGRAPHY; DTPA-CASCADE-POLYMER; FAT-SATURATION; STEADY-STATE; INTERVENTIONAL NEURORADIOLOGY; INTRACRANIAL HYPERTENSION; INITIAL-EXPERIENCE; SINUS THROMBOSIS Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49206