Universität zu Köln

Brunn, Anna, Utermoehlen, Olaf, Sanchez-Ruiz, Monica, Montesinos-Rongen, Manuel, Blau, Tobias, Schlueter, Dirk and Deckert, Martina (2010). Dual role of B cells with accelerated onset but reduced disease activity in P0(106-125)-induced experimental autoimmune neuritis of IgH(0/0) mice. Acta Neuropathol., 120 (5). S. 667 - 682. NEW YORK: SPRINGER. ISSN 1432-0533

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Abstract

The role of B cells in autoimmune-mediated diseases of the peripheral nervous system was studied in experimental autoimmune neuritis (EAN) in B cell deficient IgH(0/0) C57BL/6J mice having been immunized with P0(106-125) peptide. Compared to coisogenic IgH(+/+) mice, onset of EAN was accelerated [100% disease incidence at day 9 post immunization (p.i.) vs. day 15 p.i.]. At day 9 p.i., numbers of P0(106-125)-specific interferon (IFN)-gamma-producing CD4(+) T cells were increased, while IL-10 mRNA and production were decreased in IgH(0/0) mice. Beyond day 9 p.i., declining disease activity and a significant reduction of maximal disease activity were correlated with significantly reduced numbers of IFN-gamma-producing CD4(+) T cells in IgH(0/0) mice as compared with IgH(+/+) mice. Correspondingly, neuropathology demonstrated only mild axonal damage, while demyelination and dying back axonopathy with spinal cord motor neuron apoptosis were absent. Thus, depending on the stage of EAN, B cells play a dual, i.e. suppressive and enhancing, role during induction and at height of EAN, respectively. The combined interaction of B cells as well as CD4(+) and CD8(+) T cells is required for the development of EAN.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Brunn, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Utermoehlen, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Sanchez-Ruiz, Monica UNSPECIFIED UNSPECIFIED UNSPECIFIED Montesinos-Rongen, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Blau, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlueter, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Deckert, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-492792
DOI:	10.1007/s00401-010-0724-8
Journal or Publication Title:	Acta Neuropathol.
Volume:	120
Number:	5
Page Range:	S. 667 - 682
Date:	2010
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-0533
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXPERIMENTAL ALLERGIC NEURITIS; PERIPHERAL-NERVE MYELIN; LEWIS RATS; T-CELLS; EXTRACELLULAR DOMAIN; IMMUNE-RESPONSES; RITUXIMAB; EXPRESSION; ANTIBODY; INDUCTION Multiple languages Clinical Neurology; Neurosciences; Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49279