Metzger, Ralf, Bollschweiler, Elfriede, Hoelscher, Arnulf H. and Warnecke-Eberz, Ute (2010). ERCC1: impact in multimodality treatment of upper gastrointestinal cancer. Future Oncol., 6 (11). S. 1735 - 1750. LONDON: FUTURE MEDICINE LTD. ISSN 1744-8301

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Abstract

Platinum-based drugs and radiation are key elements of multimodality treatment in a wide variety of solid tumors and especially tumors of the upper gastrointestinal tract. Cytotoxicity is directly related to their ability to cause DNA damage. This event consecutively triggers the nucleotide excision repair (NER) complex. The NER capacity has a major impact on chemo and radiation sensitivity, emergence of resistance and patient outcome. Excision repair cross-complementing group 1 (ERCC1) is a key molecule in NER. This review provides an overview of the NER complex with a focus on ERCC1. Recent literature has been analyzed and provides information regarding the potential role of ERCC1 as a prognostic factor in multimodality treatment of upper gastrointestinal cancer and cancer risk. To date, the role of ERCC1 as a predictive marker for individual multimodality treatment is far from being firmly established for routine use. However, with reliable methods, established cut-off values and validation in large, prospective, randomized trials, ERCC1 may possibly prove to play an important role as a tumor marker in individualized treatment for upper gastrointestinal cancer.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Metzger, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bollschweiler, ElfriedeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoelscher, Arnulf H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warnecke-Eberz, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-493316
DOI: 10.2217/FON.10.140
Journal or Publication Title: Future Oncol.
Volume: 6
Number: 11
Page Range: S. 1735 - 1750
Date: 2010
Publisher: FUTURE MEDICINE LTD
Place of Publication: LONDON
ISSN: 1744-8301
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NUCLEOTIDE EXCISION-REPAIR; SQUAMOUS-CELL CARCINOMA; MESSENGER-RNA LEVELS; MINOR HISTOPATHOLOGICAL RESPONSE; GLUTATHIONE-S-TRANSFERASE; GROWTH-FACTOR RECEPTOR; DNA-REPAIR; XERODERMA-PIGMENTOSUM; GENE-EXPRESSION; NEOADJUVANT RADIOCHEMOTHERAPYMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/49331

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