Universität zu Köln

Stenner, Markus, Weinell, Antje, Ponert, Tobias, Hardt, Aline, Hahn, Moritz, Preuss, Simon F., Guntinas-Lichius, Orlando ORCID: 0000-0001-9671-0784 and Klussmann, Jens Peter ORCID: 0000-0002-8223-7954 (2010). Cytoplasmic expression of survivin is an independent predictor of poor prognosis in patients with salivary gland cancer. Histopathology, 57 (5). S. 699 - 707. HOBOKEN: WILEY. ISSN 1365-2559

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Abstract

Aims: The expression of the inhibitor of apoptosis protein survivin has been shown to be a significant prognostic indicator in various human cancers. The aim was to assess its expression and prognostic value in salivary gland adenocarcinoma and muco-epidermoid carcinoma. Methods and results: Survivin expression was analysed in 48 patients with parotid gland cancer (21 muco-epidermoid, 27 adenocarcinomas) by means of immunohistochemistry. The experimental findings were correlated with clinicopathological and survival parameters. A high cytoplasmic expression of survivin was found in 30% of the examined tumours without any significant correlation with the patients' clinicopathological characteristics (P > 0.05). Within all patients, the estimated overall survival rate of muco-epidermoid carcinomas was significantly better than that of adenocarcinomas (P = 0.013). A high cytoplasmic survivin expression significantly indicated a poor 5-year disease-free survival rate compared to patients with a low cytoplasmic survivin expression in the whole group (P = 0.001) and in adenocarcinomas (P = 0.004). In a multivariate analysis, a high cytoplasmic survivin expression was the only independent prognostic indicator for a significantly poorer 5-year disease-free survival rate (P = 0.001). Conclusions: The correlation between cytoplasmic survivin expression and survival in salivary gland malignancies might make this an effective tool in patient follow-up, prognosis and targeted therapy in future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stenner, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Weinell, Antje UNSPECIFIED UNSPECIFIED UNSPECIFIED Ponert, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Hardt, Aline UNSPECIFIED UNSPECIFIED UNSPECIFIED Hahn, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Preuss, Simon F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Guntinas-Lichius, Orlando UNSPECIFIED orcid.org/0000-0001-9671-0784 UNSPECIFIED Klussmann, Jens Peter UNSPECIFIED orcid.org/0000-0002-8223-7954 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-493369
DOI:	10.1111/j.1365-2559.2010.03693.x
Journal or Publication Title:	Histopathology
Volume:	57
Number:	5
Page Range:	S. 699 - 707
Date:	2010
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1365-2559
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MUCOEPIDERMOID CARCINOMA; NETWORKS; HEAD; P53 Multiple languages Cell Biology; Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49336