Universität zu Köln

Pukrop, Ralf and Klosterkoetter, Joachim (2010). Neurocognitive Indicators of Clinical High-Risk States for Psychosis: A Critical Review of the Evidence. Neurotox. Res., 18 (3-4). S. 272 - 287. NEW YORK: SPRINGER. ISSN 1029-8428

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Abstract

The present review investigates the empirical evidence from cross-sectional and long-term follow-up studies on neurocognitive indicators of an increased risk for developing schizophrenia spectrum psychoses in clinically defined high-risk samples. First, the investigations at the Cologne center for early recognition and intervention are briefly summarized and then integrated within the available literature. Thirty-two studies with original data could be identified by extensive literature search. Cross-sectional investigations of neurocognitive baseline assessments in high-risk samples with unknown conversion status have produced rather inconsistent results. Nevertheless, most convincing evidence could be collected for abnormal functioning in processing speed measures (digit symbol coding, Trailmaking Test-B, Stroop Color Naming), the Continuous Performance Test, verbal working memory measures, verbal memory and learning, and verbal fluency, though negative findings have also been reported in every instance. Moreover, high-risk subjects were found to perform both at the schizophrenia performance level and at a close to normal level. Longitudinal follow-up assessments provided predictive evidence with regard to psychosis conversion for measures of processing speed and of verbal memory and learning. However, a substantial number of negative findings does not allow for straight-forward conclusions. Finally, some reasons for inconsistent findings are discussed critically speculating on demographic differences, reliability and sample sizes, and conceptual imprecision in communicating results.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pukrop, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-493814
DOI:	10.1007/s12640-010-9191-1
Journal or Publication Title:	Neurotox. Res.
Volume:	18
Number:	3-4
Page Range:	S. 272 - 287
Date:	2010
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1029-8428
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ULTRA-HIGH-RISK; WORKING-MEMORY; NEUROPSYCHOLOGICAL DEFICITS; 1ST EPISODE; AT-RISK; PRODROMAL STATE; MENTAL STATE; FOLLOW-UP; SCHIZOPHRENIA; INDIVIDUALS Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49381