Universität zu Köln

Behringer, K., Wildt, L., Mueller, H., Mattle, V., Ganitis, P., van den Hoonaard, B., Ott, H. W., Hofer, S., Pluetschow, A., Diehl, V., Engert, A. and Borchmann, P. (2010). No protection of the ovarian follicle pool with the use of GnRH-analogues or oral contraceptives in young women treated with escalated BEACOPP for advanced-stage Hodgkin lymphoma. Final results of a phase II trial from the German Hodgkin Study Group. Ann. Oncol., 21 (10). S. 2052 - 2061. OXFORD: OXFORD UNIV PRESS. ISSN 1569-8041

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Abstract

Patients and methods: Women (18-40 years) were randomly assigned either to receive daily OC or monthly GnRH-a during escalated combination therapy with bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPPesc). Hormonal levels were determined at baseline, during therapy, and at follow-up. Results: The study was closed prematurely after an interim analysis of 12 patients in arm A (OC) and 11 in arm B (GnRH-a), 9 and 10 are assessable for the primary end point. Women's median age was 25 years in both arms. The anti-Mullerian hormone level after at least 12 months was reduced in all patients. For the entire study cohort, the respective ovarian follicle preservation rate was 0% (95% confidence interval 0% to 12%). Conclusion: We observed no protection of the ovarian reserve with hormonal co-treatment during BEACOPPesc. This result supports efforts of ongoing trials to reduce chemotherapy intensity and toxicity. Alternative strategies for the protection of fertility must be offered to young female HL patients before the start of BEACOPPesc therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Behringer, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wildt, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mattle, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ganitis, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED van den Hoonaard, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ott, H. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hofer, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pluetschow, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Diehl, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchmann, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-494584
DOI:	10.1093/annonc/mdq066
Journal or Publication Title:	Ann. Oncol.
Volume:	21
Number:	10
Page Range:	S. 2052 - 2061
Date:	2010
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1569-8041
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTI-MULLERIAN HORMONE; LONG-TERM SURVIVORS; FERTILITY PRESERVATION; CHILDHOOD-CANCER; BREAST-CANCER; INHIBIN-B; COMBINATION CHEMOTHERAPY; PREMATURE MENOPAUSE; MENSTRUAL-CYCLE; FEMALE-PATIENTS Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49458