Universität zu Köln

Waerzeggers, Yannic, Monfared, Parisa, Viel, Thomas ORCID: 0000-0002-0756-9166, Winkeler, Alexandra ORCID: 0000-0003-3397-2570 and Jacobs, Andreas H. (2010). Mouse models in neurological disorders: Applications of non-invasive imaging. Biochim. Biophys. Acta-Mol. Basis Dis., 1802 (10). S. 819 - 840. AMSTERDAM: ELSEVIER. ISSN 1879-260X

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Abstract

Neuroimaging techniques represent powerful tools to assess disease-specific cellular, biochemical and molecular processes non-invasively in vivo. Besides providing precise anatomical localisation and quantification, the most exciting advantage of non-invasive imaging techniques is the opportunity to investigate the spatial and temporal dynamics of disease-specific functional and molecular events longitudinally in intact living organisms, so called molecular imaging (MI). Combining neuroimaging technologies with in vivo models of neurological disorders provides unique opportunities to understand the aetiology and pathophysiology of human neurological disorders. In this way, neuroimaging in mouse models of neurological disorders not only can be used for phenotyping specific diseases and monitoring disease progression but also plays an essential role in the development and evaluation of disease-specific treatment approaches. In this way MI is a key technology in translational research, helping to design improved disease models as well as experimental treatment protocols that may afterwards be implemented into clinical routine. The most widely used imaging modalities in animal models to assess in vivo anatomical, functional and molecular events are positron emission tomography (PET), magnetic resonance imaging (MRI) and optical imaging (01). Here, we review the application of neuroimaging in mouse models of neurodegeneration (Parkinson's disease, PD, and Alzheimer's disease, AD) and brain cancer (glioma). (C) 2010 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Waerzeggers, Yannic UNSPECIFIED UNSPECIFIED UNSPECIFIED Monfared, Parisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Viel, Thomas UNSPECIFIED orcid.org/0000-0002-0756-9166 UNSPECIFIED Winkeler, Alexandra UNSPECIFIED orcid.org/0000-0003-3397-2570 UNSPECIFIED Jacobs, Andreas H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-495144
DOI:	10.1016/j.bbadis.2010.04.009
Journal or Publication Title:	Biochim. Biophys. Acta-Mol. Basis Dis.
Volume:	1802
Number:	10
Page Range:	S. 819 - 840
Date:	2010
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1879-260X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; NIGROSTRIATAL DOPAMINERGIC SYSTEM; MAGNETIC-RESONANCE-SPECTROSCOPY; ALZHEIMERS AMYLOID PLAQUES; EXPERIMENTAL BRAIN-TUMORS; ENDOTHELIAL GROWTH-FACTOR; MPTP-TREATED MONKEYS; FACTOR GENE-THERAPY; NEURAL STEM-CELLS; IN-VIVO DETECTION Multiple languages Biochemistry & Molecular Biology; Biophysics; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49514