Universität zu Köln

Fusca, Debora ORCID: 0000-0001-6089-8228 and Kloppenburg, Peter (2021). Task-specific roles of local interneurons for inter- and intraglomerular signaling in the insect antennal lobe. eLife, 10. CAMBRIDGE: eLIFE SCIENCES PUBL LTD. ISSN 2050-084X

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Abstract

Local interneurons (LNs) mediate complex interactions within the antennal lobe, the primary olfactory system of insects, and the functional analog of the vertebrate olfactory bulb. In the cockroach Periplaneta americana, as in other insects, several types of LNs with distinctive physiological and morphological properties can be defined. Here, we combined whole-cell patch-clamp recordings and Ca2+ imaging of individual LNs to analyze the role of spiking and nonspiking LNs in inter- and intraglomerular signaling during olfactory information processing. Spiking GABAergic LNs reacted to odorant stimulation with a uniform rise in [Ca2+](i) in the ramifications of all innervated glomeruli. In contrast, in nonspiking LNs, glomerular Ca2+ signals were odorant specific and varied between glomeruli, resulting in distinct, glomerulus-specific tuning curves. The cell type-specific differences in Ca2+ dynamics support the idea that spiking LNs play a primary role in interglomerular signaling, while they assign nonspiking LNs an essential role in intraglomerular signaling.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fusca, Debora UNSPECIFIED orcid.org/0000-0001-6089-8228 UNSPECIFIED Kloppenburg, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-563763
DOI:	10.7554/eLife.65217; 10.7554/eLife.65217.sa1; 10.7554/eLife.65217.sa2
Journal or Publication Title:	eLife
Volume:	10
Date:	2021
Publisher:	eLIFE SCIENCES PUBL LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UNIGLOMERULAR PROJECTION NEURONS; INTRINSIC MEMBRANE-PROPERTIES; GABA-IMMUNOREACTIVE NEURONS; PRIMARY OLFACTORY CENTER; PATCH-CLAMP RECORDINGS; PERIPLANETA-AMERICANA; SYNAPTIC CONNECTIONS; NONSPIKING INTERNEURONS; SPHINX MOTH; MORPHOLOGICAL CHARACTERIZATION Multiple languages Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56376