Albat, Dominik, Neudorfl, Jorg-Martin and Schmalz, Hans-Gunther (2021). A Short Enantioselective Synthesis of (S)-Levetiracetam through Direct Palladium-Catalyzed Asymmetric N-Allylation of Methyl 4-Aminobutyrate. Synlett, 32 (11). S. 1089 - 1093. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1437-2096
Full text not available from this repository.Abstract
An exceedingly short and enantioselective synthesis of the antiepileptic drug (S)-levetiracetam was elaborated. As the chirogenic key step, a Pd-catalyzed asymmetric N-allylation of methyl 4-aminobutyrate was achieved in the presence of only 1 mol% of a catalyst prepared in situ from [Pd(allyl)Cl](2) and a tartaric acid-derived C-2-symmetric diphosphine ligand.
Item Type: | Journal Article | ||||||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-564739 | ||||||||||||||||
DOI: | 10.1055/a-1493-9078 | ||||||||||||||||
Journal or Publication Title: | Synlett | ||||||||||||||||
Volume: | 32 | ||||||||||||||||
Number: | 11 | ||||||||||||||||
Page Range: | S. 1089 - 1093 | ||||||||||||||||
Date: | 2021 | ||||||||||||||||
Publisher: | GEORG THIEME VERLAG KG | ||||||||||||||||
Place of Publication: | STUTTGART | ||||||||||||||||
ISSN: | 1437-2096 | ||||||||||||||||
Language: | English | ||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||
Subjects: | no entry | ||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/56473 |
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