Albat, Dominik, Neudorfl, Jorg-Martin and Schmalz, Hans-Gunther (2021). A Short Enantioselective Synthesis of (S)-Levetiracetam through Direct Palladium-Catalyzed Asymmetric N-Allylation of Methyl 4-Aminobutyrate. Synlett, 32 (11). S. 1089 - 1093. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1437-2096

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Abstract

An exceedingly short and enantioselective synthesis of the antiepileptic drug (S)-levetiracetam was elaborated. As the chirogenic key step, a Pd-catalyzed asymmetric N-allylation of methyl 4-aminobutyrate was achieved in the presence of only 1 mol% of a catalyst prepared in situ from [Pd(allyl)Cl](2) and a tartaric acid-derived C-2-symmetric diphosphine ligand.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Albat, DominikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neudorfl, Jorg-MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmalz, Hans-GuntherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-564739
DOI: 10.1055/a-1493-9078
Journal or Publication Title: Synlett
Volume: 32
Number: 11
Page Range: S. 1089 - 1093
Date: 2021
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 1437-2096
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ALLYLIC SUBSTITUTION; LEVETIRACETAM; AMINATION; ESTERS; ALKYLATIONS; AGENTMultiple languages
Chemistry, OrganicMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/56473

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