Universität zu Köln

Hommen, Franziska ORCID: 0000-0002-1612-6973, Bilican, Saygin ORCID: 0000-0001-9448-6504 and Vilchez, David ORCID: 0000-0002-0801-0743 (2022). Protein clearance strategies for disease intervention. J. Neural Transm., 129 (2). S. 141 - 173. WIEN: SPRINGER WIEN. ISSN 1435-1463

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Abstract

Protein homeostasis, or proteostasis, is essential for cell function and viability. Unwanted, damaged, misfolded and aggregated proteins are degraded by the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway. Growing evidence indicates that alterations in these major proteolytic mechanisms lead to a demise in proteostasis, contributing to the onset and development of distinct diseases. Indeed, dysregulation of the UPS or autophagy is linked to several neurodegenerative, infectious and inflammatory disorders as well as cancer. Thus, modulation of protein clearance pathways is a promising approach for therapeutics. In this review, we discuss recent findings and open questions on how targeting proteolytic mechanisms could be applied for disease intervention.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hommen, Franziska UNSPECIFIED orcid.org/0000-0002-1612-6973 UNSPECIFIED Bilican, Saygin UNSPECIFIED orcid.org/0000-0001-9448-6504 UNSPECIFIED Vilchez, David UNSPECIFIED orcid.org/0000-0002-0801-0743 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-569452
DOI:	10.1007/s00702-021-02431-y
Journal or Publication Title:	J. Neural Transm.
Volume:	129
Number:	2
Page Range:	S. 141 - 173
Date:	2022
Publisher:	SPRINGER WIEN
Place of Publication:	WIEN
ISSN:	1435-1463
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UBIQUITIN-PROTEASOME SYSTEM; GLYCOGEN-SYNTHASE KINASE-3; SMALL-MOLECULE INHIBITORS; FRONTOTEMPORAL LOBAR DEGENERATION; INDUCED PARKINSONS-DISEASE; ALPHA-SYNUCLEIN CLEARANCE; NATIONAL-CANCER-INSTITUTE; LOW-DOSE LITHIUM; IN-VIVO MODELS; MOUSE MODEL Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56945