Universität zu Köln

Poptsov, Vitalii, Khatutskiy, Valery, Skokova, Anastasiia, Krasivskyi, Ihor ORCID: 0000-0003-0573-8218, Sabashnikov, Anton ORCID: 0000-0002-6289-1035, Merkle-Storms, Julia and Spirina, Ekaterina (2021). Heart transplantation from donors with left ventricular ejection fraction under forty percent. Clin. Transplant., 35 (7). HOBOKEN: WILEY. ISSN 1399-0012

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Abstract

Background Heart transplantation (HTx) remains the treatment of choice for patients with end-stage advanced heart failure. In 2016, the Shumakov National Medical Research Center commenced performing HTx from donors with abnormal left ventricular systolic function (LVEF < 40%). The aim of this study was to evaluate early and late outcomes of recipients after HTx from donors with abnormal LV systolic function. Methods Four hundred eighty seven patients underwent HTx in our institution from January 2016 to December 2018. 27 (5.5%) patients were transplanted using cardiac allografts from donors with LVEF A total of 47 donors with LVEF <40% were evaluated for potential donation. Most heart donors revealed a left ventricular ejection fraction ranging between 30% and 40%. Twenty-five recipients required urgent HTx. Four recipients presented with early allograft dysfunction. All surviving recipients demonstrated early (85.2%) or delayed (14.8%) recovery of systolic function (LVEF > 60%). Conclusion The use of dysfunctional donor hearts with impaired LV systolic function may be a realistic approach for expanding the donor pool. However, organs from such donors should be used for recipient cohorts requiring an urgent HTx, particularly for those with pretransplant mechanical circulatory support allowing for hemodynamic support in cases of early graft dysfunction in the post-transplant period.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Poptsov, Vitalii UNSPECIFIED UNSPECIFIED UNSPECIFIED Khatutskiy, Valery UNSPECIFIED UNSPECIFIED UNSPECIFIED Skokova, Anastasiia UNSPECIFIED UNSPECIFIED UNSPECIFIED Krasivskyi, Ihor UNSPECIFIED orcid.org/0000-0003-0573-8218 UNSPECIFIED Sabashnikov, Anton UNSPECIFIED orcid.org/0000-0002-6289-1035 UNSPECIFIED Merkle-Storms, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Spirina, Ekaterina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-569481
DOI:	10.1111/ctr.14341
Journal or Publication Title:	Clin. Transplant.
Volume:	35
Number:	7
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1399-0012
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARDIAC TRANSPLANTATION; DYSFUNCTION; CRITERIA; IMPACT; RECIPIENTS; SELECTION; OUTCOMES Multiple languages Surgery; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56948